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Antagonistic control of social versus repetitive self-grooming behaviors by
separable amygdala neuronal subsets
#MMPMID25215491
Hong W
; Kim DW
; Anderson DJ
Cell
2014[Sep]; 158
(6
): 1348-1361
PMID25215491
show ga
Animals display a range of innate social behaviors that play essential roles in
survival and reproduction. While the medial amygdala (MeA) has been implicated in
prototypic social behaviors such as aggression, the circuit-level mechanisms
controlling such behaviors are not well understood. Using cell-type-specific
functional manipulations, we find that distinct neuronal populations in the MeA
control different social and asocial behaviors. A GABAergic subpopulation
promotes aggression and two other social behaviors, while neighboring
glutamatergic neurons promote repetitive self-grooming, an asocial behavior.
Moreover, this glutamatergic subpopulation inhibits social interactions
independently of its effect to promote self-grooming, while the GABAergic
subpopulation inhibits self-grooming, even in a nonsocial context. These data
suggest that social versus repetitive asocial behaviors are controlled in an
antagonistic manner by inhibitory versus excitatory amygdala subpopulations,
respectively. These findings provide a framework for understanding circuit-level
mechanisms underlying opponency between innate behaviors, with implications for
their perturbation in psychiatric disorders.
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