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10.1016/j.bpj.2014.07.022 http://scihub22266oqcxt.onion/10.1016/j.bpj.2014.07.022 C4167299!4167299!25229153     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biophys+J 2014 ; 107 (6): 1462-73 Nephropedia Template TP {{tp|p=25229153|t=2014. A Mammalian Circadian Clock Model Incorporating Daytime Expression Elements |pdf=|usr=}}{{25229153}} gab.com Text A Mammalian Circadian Clock Model Incorporating Daytime Expression Elements JO: Biophys J http://www.kidney.de/pget.php?&tw=1&pmid=25229153 #FOAvip Models of the mammalian clock have traditionally been based around two feedback loops?the self-repression of Per/Cry by interfering with activation by BMAL/CLOCK, and the repression of Bmal/Clock by the REV-ERB proteins. Recent experimental evidence suggests that the D-box, a transcription factor binding site associated with daytime expression, plays a larger role in clock function than has previously been understood. We present a simplified clock model that highlights the role of the D-box and illustrate an approach for finding maximum-entropy ensembles of model parameters, given experimentally imposed constraints. Parameter variability can be mitigated using prior probability distributions derived from genome-wide studies of cellular kinetics. Our model reproduces predictions concerning the dual regulation of Cry1 by the D-box and Rev-ErbA/ROR response element (RRE) promoter elements and allows for ensemble-based predictions of phase response curves (PRCs). Nonphotic signals such as Neuropeptide Y (NPY) may act by promoting Cry1 expression, whereas photic signals likely act by stimulating expression from the E/E' box. Ensemble generation with parameter probability restraints reveals more about a model?s behavior than a single optimal parameter set. Twit Text FOAVip A Mammalian Circadian Clock Model Incorporating Daytime Expression Elements ????Biophys J http://www.kidney.de/pget.php?&tw=1&pmid=25229153 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25229153 #FOAvip English Wikipedia <ref>{{Cite pmid|25229153}}</ref> A Mammalian Circadian Clock Model Incorporating Daytime Expression Elements #MMPMID25229153 Jolley C; Ukai-Tadenuma M; Perrin D; Ueda H Biophys J 2014[Sep]; 107 (6): 1462-73 PMID25229153show ga Models of the mammalian clock have traditionally been based around two feedback loops?the self-repression of Per/Cry by interfering with activation by BMAL/CLOCK, and the repression of Bmal/Clock by the REV-ERB proteins. Recent experimental evidence suggests that the D-box, a transcription factor binding site associated with daytime expression, plays a larger role in clock function than has previously been understood. We present a simplified clock model that highlights the role of the D-box and illustrate an approach for finding maximum-entropy ensembles of model parameters, given experimentally imposed constraints. Parameter variability can be mitigated using prior probability distributions derived from genome-wide studies of cellular kinetics. Our model reproduces predictions concerning the dual regulation of Cry1 by the D-box and Rev-ErbA/ROR response element (RRE) promoter elements and allows for ensemble-based predictions of phase response curves (PRCs). Nonphotic signals such as Neuropeptide Y (NPY) may act by promoting Cry1 expression, whereas photic signals likely act by stimulating expression from the E/E' box. Ensemble generation with parameter probability restraints reveals more about a model?s behavior than a single optimal parameter set. äA Mammalian Circadian Clock Model Incorporating Daytime Expression Ele(epmc).pdf DeepDyve Pubget Overpricing