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10.1002/ajh.23784 http://scihub22266oqcxt.onion/10.1002/ajh.23784 C4167220!4167220 !24912665     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24912665 &cmd=llinks): Failed to open stream: HTTP request failed! 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Cranial radiation for pediatric T-lineage acute lymphoblastic leukemia: a systematic review and meta-analysis |pdf=|usr=}}{{24912665 }} gab.com Text Cranial radiation for pediatric T-lineage acute lymphoblastic leukemia: a systematic review and meta-analysis JO: Am J Hematol http://www.kidney.de/pget.php?&tw=1&pmid=24912665 #FOAvip There are heterogeneous approaches to cranial radiation therapy (CRT) for T-lineage acute lymphoblastic leukemia (T-ALL). We performed a systematic review of studies that specified a radiation strategy and reported survival for pediatric T-ALL. Our analysis included 62 publications reporting 78 treatment groups (patient n = 5844). The average event-free survival (EFS) was higher by 6% per 5 years (P < 0.001). Adjusting for year, EFS differed by radiation strategy. Compared to the reference group (CRT for all) which had a year-adjusted EFS of 65% (95% confidence interval, CI: 61-69%) the adjusted EFS was significantly worse (rate difference (RD)?=?-9%, 95% CI: -15 to -2%) among studies that used a risk-directed approach to CRT (P = 0.004). The adjusted EFS for the other strategies were not significantly different compared to the reference group: CRT for central nervous system positive patients only (RD = -3%, 95% CI: -14 to 7%, P = 0.49); CRT omitted for all patients (RD = 5%, 95% CI: -4 to 15%, P = 0.33). CRT may not be necessary with current chemotherapy for T-ALL. These findings, however, are susceptible to bias and caution should be applied in drawing conclusions on the comparative effectiveness of alternative CRT strategies. Twit Text FOAVip Cranial radiation for pediatric T-lineage acute lymphoblastic leukemia: a systematic review and meta-analysis ????Am J Hematol http://www.kidney.de/pget.php?&tw=1&pmid=24912665 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24912665 #FOAvip English Wikipedia <ref>{{Cite pmid|24912665 }}</ref> Cranial radiation for pediatric T-lineage acute lymphoblastic leukemia: a systematic review and meta-analysis #MMPMID24912665 Kelly MJ ; Trikalinos TA ; Dahabreh IJ ; Gianferante M ; Parsons SK Am J Hematol 2014[Oct]; 89 (10 ): 992-7 PMID24912665 show ga There are heterogeneous approaches to cranial radiation therapy (CRT) for T-lineage acute lymphoblastic leukemia (T-ALL). We performed a systematic review of studies that specified a radiation strategy and reported survival for pediatric T-ALL. Our analysis included 62 publications reporting 78 treatment groups (patient n = 5844). The average event-free survival (EFS) was higher by 6% per 5 years (P < 0.001). Adjusting for year, EFS differed by radiation strategy. Compared to the reference group (CRT for all) which had a year-adjusted EFS of 65% (95% confidence interval, CI: 61-69%) the adjusted EFS was significantly worse (rate difference (RD)?=?-9%, 95% CI: -15 to -2%) among studies that used a risk-directed approach to CRT (P = 0.004). The adjusted EFS for the other strategies were not significantly different compared to the reference group: CRT for central nervous system positive patients only (RD = -3%, 95% CI: -14 to 7%, P = 0.49); CRT omitted for all patients (RD = 5%, 95% CI: -4 to 15%, P = 0.33). CRT may not be necessary with current chemotherapy for T-ALL. These findings, however, are susceptible to bias and caution should be applied in drawing conclusions on the comparative effectiveness of alternative CRT strategies. |*Skull [MESH] |Adolescent [MESH] |Child [MESH] |Child, Preschool [MESH] |Disease-Free Survival [MESH] |Female [MESH] |Humans [MESH] |Infant [MESH] |Male [MESH] |Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/*mortality/*radiotherapy [MESH]Cranial radiation for pediatric T-lineage acute lymphoblastic leukemia(epmc).pdf DeepDyve Pubget Overpricing