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10.1152/ajprenal.00289.2014 http://scihub22266oqcxt.onion/10.1152/ajprenal.00289.2014 C4166726!4166726!25056350     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Physiol+Renal+Physiol 2014 ; 307 (6): F660-5 Nephropedia Template TP {{tp|p=25056350|t=2014. Extrarenal citrulline disposal in mice with impaired renal function |pdf=|usr=}}{{25056350}} gab.com Text Extrarenal citrulline disposal in mice with impaired renal function JO: Am J Physiol Renal Physiol http://www.kidney.de/pget.php?&tw=1&pmid=25056350 #FOAvip The endogenous synthesis of arginine, a semiessential amino acid, relies on the production of citrulline by the gut and its conversion into arginine by the kidney in what has been called the ?intestinal-renal axis? for arginine synthesis. Although the kidney is the main site for citrulline disposal, it only accounts for ?60?70% of the citrulline produced. Because the only known fate for citrulline is arginine synthesis and the enzymes that catalyze this reaction are widespread among body tissues, we hypothesized that citrulline can be utilized directly by tissues to meet, at least partially, their arginine needs. To test this hypothesis, we used stable and radioactive tracers in conscious, partially nephrectomized (½ and ?) and anesthetized acutely kidney-ligated mouse models. Nephrectomy increased plasma citrulline concentration but did not affect citrulline synthesis rates, thus reducing its clearance. Nephrectomy (?) reduced the amount of citrulline accounted for as plasma arginine from 88 to 42%. Acute kidney ligation increased the half-life and mean retention time of citrulline. Whereas the rate of citrulline conversion into plasma arginine was reduced, it was not eliminated. In addition, we observed direct utilization of citrulline for arginine synthesis and further incorporation into tissue protein in kidney-ligated mice. These observations indicate that a fraction of the citrulline produced is utilized directly by multiple tissues to meet their arginine needs and that extrarenal sites contribute to plasma arginine. Furthermore, when the interorgan synthesis of arginine is impaired, these extrarenal sites are able to increase their rate of citrulline utilization. Twit Text FOAVip Extrarenal citrulline disposal in mice with impaired renal function ????Am J Physiol Renal Physiol http://www.kidney.de/pget.php?&tw=1&pmid=25056350 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25056350 #FOAvip English Wikipedia <ref>{{Cite pmid|25056350}}</ref> Extrarenal citrulline disposal in mice with impaired renal function #MMPMID25056350 Marini JC; Didelija IC; Fiorotto ML Am J Physiol Renal Physiol 2014[Sep]; 307 (6): F660-5 PMID25056350show ga The endogenous synthesis of arginine, a semiessential amino acid, relies on the production of citrulline by the gut and its conversion into arginine by the kidney in what has been called the ?intestinal-renal axis? for arginine synthesis. Although the kidney is the main site for citrulline disposal, it only accounts for ?60?70% of the citrulline produced. Because the only known fate for citrulline is arginine synthesis and the enzymes that catalyze this reaction are widespread among body tissues, we hypothesized that citrulline can be utilized directly by tissues to meet, at least partially, their arginine needs. To test this hypothesis, we used stable and radioactive tracers in conscious, partially nephrectomized (½ and ?) and anesthetized acutely kidney-ligated mouse models. Nephrectomy increased plasma citrulline concentration but did not affect citrulline synthesis rates, thus reducing its clearance. Nephrectomy (?) reduced the amount of citrulline accounted for as plasma arginine from 88 to 42%. Acute kidney ligation increased the half-life and mean retention time of citrulline. Whereas the rate of citrulline conversion into plasma arginine was reduced, it was not eliminated. In addition, we observed direct utilization of citrulline for arginine synthesis and further incorporation into tissue protein in kidney-ligated mice. These observations indicate that a fraction of the citrulline produced is utilized directly by multiple tissues to meet their arginine needs and that extrarenal sites contribute to plasma arginine. Furthermore, when the interorgan synthesis of arginine is impaired, these extrarenal sites are able to increase their rate of citrulline utilization. äExtrarenal citrulline disposal in mice with impaired renal function (epmc).pdf DeepDyve Pubget Overpricing