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2014 ; 28
(9
): 1080-6; quiz 1087
Nephropedia Template TP
gab.com Text
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English Wikipedia
Refractive errors after the use of bevacizumab for the treatment of retinopathy
of prematurity: 2-year outcomes
#MMPMID25104736
Chen YH
; Chen SN
; Lien RI
; Shih CP
; Chao AN
; Chen KJ
; Hwang YS
; Wang NK
; Chen YP
; Lee KH
; Chuang CC
; Chen TL
; Lai CC
; Wu WC
Eye (Lond)
2014[Sep]; 28
(9
): 1080-6; quiz 1087
PMID25104736
show ga
PURPOSE: To evaluate the refractive outcomes in children treated after
intravitreal injection of bevacizumab (IVB) for retinopathy of prematurity (ROP).
METHODS: A retrospective, bi-centre study of 34 patients (64 eyes) was conducted.
The patients were divided into three groups, patients received intravitreal IVB
(IVB group), patients received combined IVB and laser treatment (IVB + Laser
group), or patients received lens-sparing vitrectomy (IVB + LSV group).
Cycloplegic refraction and axial length (AXL) were evaluated at 2 years old.
RESULTS: The prevalences of myopia and high myopia were 47.5 and 10.0% in the IVB
group, respectively, which were lower than those in the IVB + Laser (82.4 and
29.4%) and IVB + LSV (all 100%) groups (P = 0.001 and P < 0.001). The prevalences
of emmetropia in the IVB group, IVB + Laser group, and IVB + LSV group were 50,
5.9, and 0% (P = 0.001). The AXL were similar among all groups. CONCLUSIONS: At
the 2-year follow-up, severe ROP patients treated with IVB alone were more likely
to remain emmetropic and had lower prevalences of myopia and high myopia. The
development of high myopia in severe ROP patients could not be explained by AXL
changes but may be associated with abnormalities in the anterior segment.
|Angiogenesis Inhibitors/*therapeutic use
[MESH]
|Antibodies, Monoclonal, Humanized/*therapeutic use
[MESH]