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10.1038/eye.2014.145 http://scihub22266oqcxt.onion/10.1038/eye.2014.145 C4166635!4166635!24971990     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Eye+(Lond) 2014 ; 28 (9): 1066-79 Nephropedia Template TP {{tp|p=24971990|t=2014. Genome-wide association studies: applications and insights gained in Ophthalmology |pdf=|usr=}}{{24971990}} gab.com Text Genome-wide association studies: applications and insights gained in Ophthalmology JO: Eye (Lond) http://www.kidney.de/pget.php?&tw=1&pmid=24971990 #FOAvip Genome-wide association studies (GWAS) use high-throughput genotyping technologies to genotype thousands of single-nucleotide polymorphisms (SNPs) and relate them to the development of clinical and quantitative traits. Their use has been highly successful in the field of ophthalmology, and since the advent of GWAS in 2005, many genes not previously suspected of having a role in disease have been identified and the findings replicated. We conducted an extensive literature review and describe the concept, design, advantages, and limitations of GWAS and provide a detailed description of the applications and discoveries of GWAS in the field of eye disease to date. There have been many novel findings revealing previously unknown biological insights in a diverse range of common ocular conditions. GWAS have been a highly successful modality for investigating the pathogenesis of a wide variety of ophthalmic conditions. The insights gained into the pathogenesis of disease provide not only a better understanding of underlying disease mechanism but also offer a rationale for targeted treatment and preventative strategies. Expansive international collaboration and standardised phenotyping will permit the continued success of this investigative technique. Twit Text FOAVip Genome-wide association studies: applications and insights gained in Ophthalmology ????Eye (Lond) http://www.kidney.de/pget.php?&tw=1&pmid=24971990 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24971990 #FOAvip English Wikipedia <ref>{{Cite pmid|24971990}}</ref> Genome-wide association studies: applications and insights gained in Ophthalmology #MMPMID24971990 Chandra A; Mitry D; Wright A; Campbell H; Charteris DG Eye (Lond) 2014[Sep]; 28 (9): 1066-79 PMID24971990show ga Genome-wide association studies (GWAS) use high-throughput genotyping technologies to genotype thousands of single-nucleotide polymorphisms (SNPs) and relate them to the development of clinical and quantitative traits. Their use has been highly successful in the field of ophthalmology, and since the advent of GWAS in 2005, many genes not previously suspected of having a role in disease have been identified and the findings replicated. We conducted an extensive literature review and describe the concept, design, advantages, and limitations of GWAS and provide a detailed description of the applications and discoveries of GWAS in the field of eye disease to date. There have been many novel findings revealing previously unknown biological insights in a diverse range of common ocular conditions. GWAS have been a highly successful modality for investigating the pathogenesis of a wide variety of ophthalmic conditions. The insights gained into the pathogenesis of disease provide not only a better understanding of underlying disease mechanism but also offer a rationale for targeted treatment and preventative strategies. Expansive international collaboration and standardised phenotyping will permit the continued success of this investigative technique. äGenome-wide association studies: applications and insights gained in O(epmc).pdf DeepDyve Pubget Overpricing