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10.1016/j.canlet.2014.04.003 http://scihub22266oqcxt.onion/10.1016/j.canlet.2014.04.003 C4166407!4166407!24732808     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cancer+Lett 2014 ; 349 (1): 8-14 Nephropedia Template TP {{tp|p=24732808|t=2014. Multi-targeted therapy of cancer by niclosamide: a new application for an old drug |pdf=|usr=}}{{24732808}} gab.com Text Multi-targeted therapy of cancer by niclosamide: a new application for an old drug JO: Cancer Lett http://www.kidney.de/pget.php?&tw=1&pmid=24732808 #FOAvip The rapid development of new anticancer drugs that are safe and effective is a common goal shared by basic scientists, clinicians and patients. The current review discusses one such agent, namely niclosamide, which has been used in the clinic for the treatment of intestinal parasite infections. Recent studies repeatedly identified niclosamide as a potential anticancer agent by various high-throughput screening campaigns. Niclosamide not only inhibits the Wnt/?-catenin, mTORC1, STAT3, NF-?B and Notch signaling pathways, but also targets mitochondria in cancer cells to induce cell cycle arrest, growth inhibition and apoptosis. A number of studies have established the anticancer activities of niclosamide in both in vitro and in vivo models. Moreover, the inhibitory effects of niclosamide on cancer stem cells provide further evidence for its consideration as a promising drug for cancer therapy. This article reviews various aspects of niclosamide as they relate to its efficacy against cancer and associated molecular mechanisms. Twit Text FOAVip Multi-targeted therapy of cancer by niclosamide: a new application for an old drug ????Cancer Lett http://www.kidney.de/pget.php?&tw=1&pmid=24732808 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24732808 #FOAvip English Wikipedia <ref>{{Cite pmid|24732808}}</ref> Multi-targeted therapy of cancer by niclosamide: a new application for an old drug #MMPMID24732808 Li Y; Li PK; Roberts MJ; Arend R; Samant RS; Buchsbaum DJ Cancer Lett 2014[Jul]; 349 (1): 8-14 PMID24732808show ga The rapid development of new anticancer drugs that are safe and effective is a common goal shared by basic scientists, clinicians and patients. The current review discusses one such agent, namely niclosamide, which has been used in the clinic for the treatment of intestinal parasite infections. Recent studies repeatedly identified niclosamide as a potential anticancer agent by various high-throughput screening campaigns. Niclosamide not only inhibits the Wnt/?-catenin, mTORC1, STAT3, NF-?B and Notch signaling pathways, but also targets mitochondria in cancer cells to induce cell cycle arrest, growth inhibition and apoptosis. A number of studies have established the anticancer activities of niclosamide in both in vitro and in vivo models. Moreover, the inhibitory effects of niclosamide on cancer stem cells provide further evidence for its consideration as a promising drug for cancer therapy. This article reviews various aspects of niclosamide as they relate to its efficacy against cancer and associated molecular mechanisms. äMulti-targeted therapy of cancer by niclosamide: a new application for(epmc).pdf DeepDyve Pubget Overpricing