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10.1016/j.bbadis.2014.05.028 http://scihub22266oqcxt.onion/10.1016/j.bbadis.2014.05.028 C4165798!4165798!24892209     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biochim+Biophys+Acta 2014 ; 1842 (10): 1971-80 Nephropedia Template TP {{tp|p=24892209|t=2014. Protein-protein interactions and genetic diseases: The Interactome |pdf=|usr=}}{{24892209}} gab.com Text Protein-protein interactions and genetic diseases: The Interactome JO: Biochim Biophys Acta http://www.kidney.de/pget.php?&tw=1&pmid=24892209 #FOAvip Protein-protein interactions mediate essentially all biological processes. Despite the quality of these data being widely questioned a decade ago, the reproducibility of large-scale protein interaction data is now much improved and there is little question that the latest screens are of high quality. Moreover, common data standards and coordinated curation practices between the databases that collect the interactions have made these valuable data available to a wide group of researchers. Here, I will review how protein-protein interactions are measured, collected and quality controlled. I discuss how the architecture of molecular protein networks have informed disease biology, and how these data are now being computationally integrated with the newest genomic technologies, in particular genome-wide association studies and exome-sequencing projects, to improve our understanding of molecular processes perturbed by genetics in human diseases. Twit Text FOAVip Protein-protein interactions and genetic diseases: The Interactome ????Biochim Biophys Acta http://www.kidney.de/pget.php?&tw=1&pmid=24892209 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24892209 #FOAvip English Wikipedia <ref>{{Cite pmid|24892209}}</ref> Protein-protein interactions and genetic diseases: The Interactome #MMPMID24892209 Lage K Biochim Biophys Acta 2014[Oct]; 1842 (10): 1971-80 PMID24892209show ga Protein-protein interactions mediate essentially all biological processes. Despite the quality of these data being widely questioned a decade ago, the reproducibility of large-scale protein interaction data is now much improved and there is little question that the latest screens are of high quality. Moreover, common data standards and coordinated curation practices between the databases that collect the interactions have made these valuable data available to a wide group of researchers. Here, I will review how protein-protein interactions are measured, collected and quality controlled. I discuss how the architecture of molecular protein networks have informed disease biology, and how these data are now being computationally integrated with the newest genomic technologies, in particular genome-wide association studies and exome-sequencing projects, to improve our understanding of molecular processes perturbed by genetics in human diseases. äProtein-protein interactions and genetic diseases: The Interactome (epmc).pdf DeepDyve Pubget Overpricing