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10.1002/eji.201344322 http://scihub22266oqcxt.onion/10.1002/eji.201344322 C4165787!4165787!24975032     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Eur+J+Immunol 2014 ; 44 (9): 2785-801 Nephropedia Template TP {{tp|p=24975032|t=2014. Insertional hypermutation in mineral oil-induced plasmacytomas |pdf=|usr=}}{{24975032}} gab.com Text Insertional hypermutation in mineral oil-induced plasmacytomas JO: Eur J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=24975032 #FOAvip Unless stimulated by a chronic inflammatory agent such as mineral oil, plasma cell tumors are rare in young BALB/c mice. This raises the questions, What do inflammatory tissues provide to promote mutagenesis? and What is the nature of mutagenesis? We determined that mineral oil-induced plasmacytomas produce large amounts of endogenous retroelements?ecotropic and polytropic murine leukemia virus and intracisternal A-particles. Therefore, plasmacytoma formation might occur, in part, by de novo insertion of these retroelements, induced or helped by the inflammation. We recovered up to 10 de novo insertions in a single plasmacytoma, mostly in genes with common retroviral integration sites. Additional integrations accompany tumor evolution from a solid tumor through several generations in cell culture. The high frequency of de novo integrations into cancer genes suggests that endogenous retroelements are coresponsible for plasmacytoma formation and progression in BALB/c mice. Twit Text FOAVip Insertional hypermutation in mineral oil-induced plasmacytomas ????Eur J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=24975032 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24975032 #FOAvip English Wikipedia <ref>{{Cite pmid|24975032}}</ref> Insertional hypermutation in mineral oil-induced plasmacytomas #MMPMID24975032 Knittel G; Metzner M; Beck-Engeser G; Kan A; Ahrends T; Eilat D; Huppi K; Wabl M Eur J Immunol 2014[Sep]; 44 (9): 2785-801 PMID24975032show ga Unless stimulated by a chronic inflammatory agent such as mineral oil, plasma cell tumors are rare in young BALB/c mice. This raises the questions, What do inflammatory tissues provide to promote mutagenesis? and What is the nature of mutagenesis? We determined that mineral oil-induced plasmacytomas produce large amounts of endogenous retroelements?ecotropic and polytropic murine leukemia virus and intracisternal A-particles. Therefore, plasmacytoma formation might occur, in part, by de novo insertion of these retroelements, induced or helped by the inflammation. We recovered up to 10 de novo insertions in a single plasmacytoma, mostly in genes with common retroviral integration sites. Additional integrations accompany tumor evolution from a solid tumor through several generations in cell culture. The high frequency of de novo integrations into cancer genes suggests that endogenous retroelements are coresponsible for plasmacytoma formation and progression in BALB/c mice. äInsertional hypermutation in mineral oil-induced plasmacytomas (epmc).pdf DeepDyve Pubget Overpricing