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10.1002/eji.201344423 http://scihub22266oqcxt.onion/10.1002/eji.201344423 C4165701!4165701!24975127     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Eur+J+Immunol 2014 ; 44 (9): 2603-16 Nephropedia Template TP {{tp|p=24975127|t=2014. PD-1 regulates extrathymic regulatory T-cell differentiation |pdf=|usr=}}{{24975127}} gab.com Text PD-1 regulates extrathymic regulatory T-cell differentiation JO: Eur J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=24975127 #FOAvip Regulatory T (Treg) cells and the programmed death-1/programmed death ligand-1 (PD-1/PD-L1) pathway are both critical for maintaining peripheral tolerance to self antigens. A significant subset of Treg cells constitutively expresses PD-1, which prompted an investigation into the role of PD-1/PD-L1 interactions in Treg-cell development, function and induction in vivo. The phenotype and abundance of Treg cells was not significantly altered in PD-1-deficient mice. The thymic development of polyclonal and monospecific Treg cells was not negatively impacted by PD-1 deficiency. The suppressive function of PD-1?/? Treg cells was similar to their PD-1+/+ counterparts both in vitro and in vivo. However, in three different in vivo experimental settings, PD-1?/? conventional CD4+ T cells demonstrated a strikingly diminished tendency toward differentiation into peripherally induced Treg (pTreg) cells. Our results demonstrate that PD-1 is dispensable for thymic (tTreg) Treg-cell development and suppressive function, but is critical for the extrathymic differentiation of pTreg cells in vivo. These data suggest that antibody blockade of the PD-1/PD-L1 pathway may augment T-cell responses by acting directly on conventional T cells, and also by suppressing the differentiation of pTreg cells. Twit Text FOAVip PD-1 regulates extrathymic regulatory T-cell differentiation ????Eur J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=24975127 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24975127 #FOAvip English Wikipedia <ref>{{Cite pmid|24975127}}</ref> PD-1 regulates extrathymic regulatory T-cell differentiation #MMPMID24975127 Chen X; Fosco D; Kline DE; Meng L; Nishi S; Savage PA; Kline J Eur J Immunol 2014[Sep]; 44 (9): 2603-16 PMID24975127show ga Regulatory T (Treg) cells and the programmed death-1/programmed death ligand-1 (PD-1/PD-L1) pathway are both critical for maintaining peripheral tolerance to self antigens. A significant subset of Treg cells constitutively expresses PD-1, which prompted an investigation into the role of PD-1/PD-L1 interactions in Treg-cell development, function and induction in vivo. The phenotype and abundance of Treg cells was not significantly altered in PD-1-deficient mice. The thymic development of polyclonal and monospecific Treg cells was not negatively impacted by PD-1 deficiency. The suppressive function of PD-1?/? Treg cells was similar to their PD-1+/+ counterparts both in vitro and in vivo. However, in three different in vivo experimental settings, PD-1?/? conventional CD4+ T cells demonstrated a strikingly diminished tendency toward differentiation into peripherally induced Treg (pTreg) cells. Our results demonstrate that PD-1 is dispensable for thymic (tTreg) Treg-cell development and suppressive function, but is critical for the extrathymic differentiation of pTreg cells in vivo. These data suggest that antibody blockade of the PD-1/PD-L1 pathway may augment T-cell responses by acting directly on conventional T cells, and also by suppressing the differentiation of pTreg cells. äPD-1 regulates extrathymic regulatory T-cell differentiation (epmc).pdf DeepDyve Pubget Overpricing