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10.1016/j.neuroscience.2014.06.018 http://scihub22266oqcxt.onion/10.1016/j.neuroscience.2014.06.018 C4165556!4165556!24952333     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Neuroscience 2014 ; 275 (ä): 340-51 Nephropedia Template TP {{tp|p=24952333|t=2014. Graded defragmentation of cortical neuronal firing during recovery of consciousness in rats |pdf=|usr=}}{{24952333}} gab.com Text Graded defragmentation of cortical neuronal firing during recovery of consciousness in rats JO: Neuroscience http://www.kidney.de/pget.php?&tw=1&pmid=24952333 #FOAvip State-dependent neuronal firing patterns reflect changes in ongoing information processing and cortical function. A disruption of neuronal coordination has been suggested as the neural correlate of anesthesia. Here, we studied the temporal correlation patterns of ongoing spike activity, during a stepwise reduction of the volatile anesthetic desflurane, in the cerebral cortex of freely moving rats. We hypothesized that the recovery of consciousness from general anesthesia is accompanied by specific changes in the spatiotemporal pattern and correlation of neuronal activity. Sixty-four contact microelectrode arrays were chronically implanted in primary visual cortex (contacts spanning 1.4 mm depth and 1.4 mm width) for recording of extracellular unit activity at four steady-state levels of anesthesia (8%?2% desflurane) and wakefulness. Recovery of consciousness was defined as the regaining of the righting reflex (near 4%). High-intensity firing (HI) periods were segmented using a threshold (200 ms) representing the minimum in the neurons? bimodal interspike interval histogram under anesthesia. We found that the HI periods were highly fragmented in deep anesthesia and gradually transformed to a near-continuous firing pattern at wakefulness. As the anesthetic was withdrawn, HI periods became longer and increasingly correlated among the units both locally and across remote recording sites. Paradoxically, in 4 of 8 animals, HI correlation was also high at the deepest level of anesthesia (8%) when local field potentials (LFP) were burst-suppressed. We conclude that recovery from desflurane anesthesia is accompanied by a graded defragmentation of neuronal activity in the cerebral cortex. Hypersynchrony during deep anesthesia is an exception that occurs only with LFP burst suppression. Twit Text FOAVip Graded defragmentation of cortical neuronal firing during recovery of consciousness in rats ????Neuroscience http://www.kidney.de/pget.php?&tw=1&pmid=24952333 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24952333 #FOAvip English Wikipedia <ref>{{Cite pmid|24952333}}</ref> Graded defragmentation of cortical neuronal firing during recovery of consciousness in rats #MMPMID24952333 VIZUETE JA; PILLAY S; ROPELLA KM; HUDETZ AG Neuroscience 2014[Sep]; 275 (ä): 340-51 PMID24952333show ga State-dependent neuronal firing patterns reflect changes in ongoing information processing and cortical function. A disruption of neuronal coordination has been suggested as the neural correlate of anesthesia. Here, we studied the temporal correlation patterns of ongoing spike activity, during a stepwise reduction of the volatile anesthetic desflurane, in the cerebral cortex of freely moving rats. We hypothesized that the recovery of consciousness from general anesthesia is accompanied by specific changes in the spatiotemporal pattern and correlation of neuronal activity. Sixty-four contact microelectrode arrays were chronically implanted in primary visual cortex (contacts spanning 1.4 mm depth and 1.4 mm width) for recording of extracellular unit activity at four steady-state levels of anesthesia (8%?2% desflurane) and wakefulness. Recovery of consciousness was defined as the regaining of the righting reflex (near 4%). High-intensity firing (HI) periods were segmented using a threshold (200 ms) representing the minimum in the neurons? bimodal interspike interval histogram under anesthesia. We found that the HI periods were highly fragmented in deep anesthesia and gradually transformed to a near-continuous firing pattern at wakefulness. As the anesthetic was withdrawn, HI periods became longer and increasingly correlated among the units both locally and across remote recording sites. Paradoxically, in 4 of 8 animals, HI correlation was also high at the deepest level of anesthesia (8%) when local field potentials (LFP) were burst-suppressed. We conclude that recovery from desflurane anesthesia is accompanied by a graded defragmentation of neuronal activity in the cerebral cortex. Hypersynchrony during deep anesthesia is an exception that occurs only with LFP burst suppression. äGraded defragmentation of cortical neuronal firing during recovery of (epmc).pdf DeepDyve Pubget Overpricing