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10.1016/j.molcel.2014.03.047 http://scihub22266oqcxt.onion/10.1016/j.molcel.2014.03.047 C4165194!4165194!24793695     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Cell 2014 ; 54 (5): 791-804 Nephropedia Template TP {{tp|p=24793695|t=2014. The 3M complex maintains microtubule and genome integrity |pdf=|usr=}}{{24793695}} gab.com Text The 3M complex maintains microtubule and genome integrity JO: Mol Cell http://www.kidney.de/pget.php?&tw=1&pmid=24793695 #FOAvip CUL7, OBSL1, and CCDC8 genes are mutated in a mutually exclusive manner in 3M and other growth retardation syndromes. The mechanism underlying the function of the three 3M genes in development is not known. We found that OBSL1 and CCDC8 form a complex with CUL7 and regulate the level and centrosomal localization of CUL7, respectively. CUL7 depletion results in altered microtubule dynamics, prometaphase arrest, tetraploidy and mitotic cell death. These defects are recaptured in CUL7 mutated 3M cells and can be rescued by wild-type, but not 3M patients-derived CUL7 mutants. Depletion of either OBSL1 or CCDC8 results in similar defects and sensitizes cells to microtubule damage as loss of CUL7 function. Microtubule damage reduces the level of CCDC8 that is required for the centrosomal localization of CUL7. We propose that CUL7, OBSL1, and CCDC8 proteins form a 3M complex that functions in maintaining microtubule and genome integrity and normal development. Twit Text FOAVip The 3M complex maintains microtubule and genome integrity ????Mol Cell http://www.kidney.de/pget.php?&tw=1&pmid=24793695 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24793695 #FOAvip English Wikipedia <ref>{{Cite pmid|24793695}}</ref> The 3M complex maintains microtubule and genome integrity #MMPMID24793695 Yan J; Yan F; Li Z; Sinnott B; Cappell KM; Yu Y; Mo J; Duncan JA; Chen X; Cormier-Daire V; Whitehurst AW; Xiong Y Mol Cell 2014[Jun]; 54 (5): 791-804 PMID24793695show ga CUL7, OBSL1, and CCDC8 genes are mutated in a mutually exclusive manner in 3M and other growth retardation syndromes. The mechanism underlying the function of the three 3M genes in development is not known. We found that OBSL1 and CCDC8 form a complex with CUL7 and regulate the level and centrosomal localization of CUL7, respectively. CUL7 depletion results in altered microtubule dynamics, prometaphase arrest, tetraploidy and mitotic cell death. These defects are recaptured in CUL7 mutated 3M cells and can be rescued by wild-type, but not 3M patients-derived CUL7 mutants. Depletion of either OBSL1 or CCDC8 results in similar defects and sensitizes cells to microtubule damage as loss of CUL7 function. Microtubule damage reduces the level of CCDC8 that is required for the centrosomal localization of CUL7. We propose that CUL7, OBSL1, and CCDC8 proteins form a 3M complex that functions in maintaining microtubule and genome integrity and normal development. äThe 3M complex maintains microtubule and genome integrity (epmc).pdf DeepDyve Pubget Overpricing