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10.1016/j.neuroscience.2014.06.053

http://scihub22266oqcxt.onion/10.1016/j.neuroscience.2014.06.053
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suck abstract from ncbi


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pmid24998895      Neuroscience 2014 ; ä (ä): 139-51
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  • Alcohol, stress hormones, and the prefrontal cortex: a proposed pathway to the dark side of addiction #MMPMID24998895
  • Lu YL; Richardson HN
  • Neuroscience 2014[Sep]; ä (ä): 139-51 PMID24998895show ga
  • Chronic exposure to alcohol produces changes in the prefrontal cortex that are thought to contribute to the development and maintenance of alcoholism. A large body of literature suggests that stress hormones play a critical role in this process. Here we review the bi-directional relationship between alcohol and stress hormones, and discuss how alcohol acutely stimulates the release of glucocorticoids and induces enduring modifications to neuroendocrine stress circuits during the transition from non-dependent drinking to alcohol dependence. We propose a pathway by which alcohol and stress hormones elicit neuroadaptive changes in prefrontal circuitry that could contribute functionally to a dampened neuroendocrine state and the increased propensity to relapse?a spiraling trajectory that could eventually lead to dependence.
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