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10.1016/j.neuroscience.2014.06.053

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suck abstract from ncbi


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pmid24998895
      Neuroscience 2014 ; 277 (ä): 139-51
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  • Alcohol, stress hormones, and the prefrontal cortex: a proposed pathway to the dark side of addiction #MMPMID24998895
  • Lu YL ; Richardson HN
  • Neuroscience 2014[Sep]; 277 (ä): 139-51 PMID24998895 show ga
  • Chronic exposure to alcohol produces changes in the prefrontal cortex that are thought to contribute to the development and maintenance of alcoholism. A large body of literature suggests that stress hormones play a critical role in this process. Here we review the bi-directional relationship between alcohol and stress hormones, and discuss how alcohol acutely stimulates the release of glucocorticoids and induces enduring modifications to neuroendocrine stress circuits during the transition from non-dependent drinking to alcohol dependence. We propose a pathway by which alcohol and stress hormones elicit neuroadaptive changes in prefrontal circuitry that could contribute functionally to a dampened neuroendocrine state and the increased propensity to relapse-a spiraling trajectory that could eventually lead to dependence.
  • |Alcohol Drinking/physiopathology [MESH]
  • |Alcohol-Related Disorders/*physiopathology [MESH]
  • |Animals [MESH]
  • |Behavior, Addictive/physiopathology [MESH]
  • |Central Nervous System Depressants/*pharmacology [MESH]
  • |Ethanol/*pharmacology [MESH]
  • |Glucocorticoids/*metabolism [MESH]
  • |Humans [MESH]


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