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2014 ; 277
(ä): 139-51
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Alcohol, stress hormones, and the prefrontal cortex: a proposed pathway to the
dark side of addiction
#MMPMID24998895
Lu YL
; Richardson HN
Neuroscience
2014[Sep]; 277
(ä): 139-51
PMID24998895
show ga
Chronic exposure to alcohol produces changes in the prefrontal cortex that are
thought to contribute to the development and maintenance of alcoholism. A large
body of literature suggests that stress hormones play a critical role in this
process. Here we review the bi-directional relationship between alcohol and
stress hormones, and discuss how alcohol acutely stimulates the release of
glucocorticoids and induces enduring modifications to neuroendocrine stress
circuits during the transition from non-dependent drinking to alcohol dependence.
We propose a pathway by which alcohol and stress hormones elicit neuroadaptive
changes in prefrontal circuitry that could contribute functionally to a dampened
neuroendocrine state and the increased propensity to relapse-a spiraling
trajectory that could eventually lead to dependence.