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10.1016/j.cell.2014.08.032 http://scihub22266oqcxt.onion/10.1016/j.cell.2014.08.032 C4164201!4164201 !25215495     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25215495 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell 2014 ; 158 (6 ): 1402-1414 Nephropedia Template TP {{tp|p=25215495 |t=2014. A systematic analysis of biosynthetic gene clusters in the human microbiome reveals a common family of antibiotics |pdf=|usr=}}{{25215495 }} gab.com Text A systematic analysis of biosynthetic gene clusters in the human microbiome reveals a common family of antibiotics JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=25215495 #FOAvip In complex biological systems, small molecules often mediate microbe-microbe and microbe-host interactions. Using a systematic approach, we identified 3,118 small-molecule biosynthetic gene clusters (BGCs) in genomes of human-associated bacteria and studied their representation in 752 metagenomic samples from the NIH Human Microbiome Project. Remarkably, we discovered that BGCs for a class of antibiotics in clinical trials, thiopeptides, are widely distributed in genomes and metagenomes of the human microbiota. We purified and solved the structure of a thiopeptide antibiotic, lactocillin, from a prominent member of the vaginal microbiota. We demonstrate that lactocillin has potent antibacterial activity against a range of Gram-positive vaginal pathogens, and we show that lactocillin and other thiopeptide BGCs are expressed in vivo by analyzing human metatranscriptomic sequencing data. Our findings illustrate the widespread distribution of small-molecule-encoding BGCs in the human microbiome, and they demonstrate the bacterial production of drug-like molecules in humans. PAPERCLIP: Twit Text FOAVip A systematic analysis of biosynthetic gene clusters in the human microbiome reveals a common family of antibiotics ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=25215495 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25215495 #FOAvip English Wikipedia <ref>{{Cite pmid|25215495 }}</ref> A systematic analysis of biosynthetic gene clusters in the human microbiome reveals a common family of antibiotics #MMPMID25215495 Donia MS ; Cimermancic P ; Schulze CJ ; Wieland Brown LC ; Martin J ; Mitreva M ; Clardy J ; Linington RG ; Fischbach MA Cell 2014[Sep]; 158 (6 ): 1402-1414 PMID25215495 show ga In complex biological systems, small molecules often mediate microbe-microbe and microbe-host interactions. Using a systematic approach, we identified 3,118 small-molecule biosynthetic gene clusters (BGCs) in genomes of human-associated bacteria and studied their representation in 752 metagenomic samples from the NIH Human Microbiome Project. Remarkably, we discovered that BGCs for a class of antibiotics in clinical trials, thiopeptides, are widely distributed in genomes and metagenomes of the human microbiota. We purified and solved the structure of a thiopeptide antibiotic, lactocillin, from a prominent member of the vaginal microbiota. We demonstrate that lactocillin has potent antibacterial activity against a range of Gram-positive vaginal pathogens, and we show that lactocillin and other thiopeptide BGCs are expressed in vivo by analyzing human metatranscriptomic sequencing data. Our findings illustrate the widespread distribution of small-molecule-encoding BGCs in the human microbiome, and they demonstrate the bacterial production of drug-like molecules in humans. PAPERCLIP: |*Microbiota [MESH] |Amino Acid Sequence [MESH] |Bacteria/*chemistry/classification/*genetics/metabolism [MESH] |Biosynthetic Pathways [MESH] |Gastrointestinal Tract/microbiology [MESH] |Humans [MESH] |Metagenomics/*methods [MESH] |Molecular Sequence Data [MESH] |Mouth/microbiology [MESH] |Multigene Family [MESH] |Peptide Biosynthesis, Nucleic Acid-Independent [MESH]A systematic analysis of biosynthetic gene clusters in the human micro(epmc).pdf DeepDyve Pubget Overpricing