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10.1016/j.semnephrol.2014.06.007 http://scihub22266oqcxt.onion/10.1016/j.semnephrol.2014.06.007 C4163949!4163949!25217269     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Semin+Nephrol 2014 ; 34 (4): 404-17 Nephropedia Template TP {{tp|p=25217269|t=2014. Defining the Renal Repair Transcriptome after Acute Kidney Injury |pdf=|usr=}}{{25217269}} gab.com Text Defining the Renal Repair Transcriptome after Acute Kidney Injury JO: Semin Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=25217269 #FOAvip The mammalian kidney has an intrinsic ability to repair after significant injury. However, this process is inefficient: patients are at high risk for the loss of kidney function in later life. No therapy exists to treat established acute kidney injury (AKI) per se: strategies to promote endogenous repair processes, and retard associated fibrosis are a high priority. Whole-organ gene expression profiling has been used to identify repair responses initiated on AKI, and factors that may promote the transition from AKI to chronic kidney disease (CKD). Transcriptional profiling has revealed molecular markers and potential regulatory pathways of renal repair. Activation of a few key developmental pathways has been reported during repair. Whether these are comparable networks with similar target genes to those in earlier nephrogenesis remains unclear. Altered microRNA profiles, persistent tubular injury responses, and distinct late inflammatory responses highlight continuing kidney pathology. Additional insights into injury and repair processes will be gained by study of the repair transcriptome and cell-specific translatome utilizing high-resolution technologies such as RNA sequencing and translational profiling tailored to specific cellular compartments within the kidney. An enhanced understanding holds promise for both the identification of novel therapeutic targets and biomarker-based evaluation of the damage-repair process. Twit Text FOAVip Defining the Renal Repair Transcriptome after Acute Kidney Injury ????Semin Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=25217269 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25217269 #FOAvip English Wikipedia <ref>{{Cite pmid|25217269}}</ref> Defining the Renal Repair Transcriptome after Acute Kidney Injury #MMPMID25217269 Kumar S; Liu J; McMahon AP Semin Nephrol 2014[Jul]; 34 (4): 404-17 PMID25217269show ga The mammalian kidney has an intrinsic ability to repair after significant injury. However, this process is inefficient: patients are at high risk for the loss of kidney function in later life. No therapy exists to treat established acute kidney injury (AKI) per se: strategies to promote endogenous repair processes, and retard associated fibrosis are a high priority. Whole-organ gene expression profiling has been used to identify repair responses initiated on AKI, and factors that may promote the transition from AKI to chronic kidney disease (CKD). Transcriptional profiling has revealed molecular markers and potential regulatory pathways of renal repair. Activation of a few key developmental pathways has been reported during repair. Whether these are comparable networks with similar target genes to those in earlier nephrogenesis remains unclear. Altered microRNA profiles, persistent tubular injury responses, and distinct late inflammatory responses highlight continuing kidney pathology. Additional insights into injury and repair processes will be gained by study of the repair transcriptome and cell-specific translatome utilizing high-resolution technologies such as RNA sequencing and translational profiling tailored to specific cellular compartments within the kidney. An enhanced understanding holds promise for both the identification of novel therapeutic targets and biomarker-based evaluation of the damage-repair process. äDefining the Renal Repair Transcriptome after Acute Kidney Injury (epmc).pdf DeepDyve Pubget Overpricing