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10.1158/1541-7786.MCR-14-0170 http://scihub22266oqcxt.onion/10.1158/1541-7786.MCR-14-0170 C4163536!4163536!25061102     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Cancer+Res 2014 ; 12 (9): 1314-23 Nephropedia Template TP {{tp|p=25061102|t=2014. FOXD3 Modulates Migration Through Direct Transcriptional Repression of TWIST1 in melanoma |pdf=|usr=}}{{25061102}} gab.com Text FOXD3 Modulates Migration Through Direct Transcriptional Repression of TWIST1 in melanoma JO: Mol Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=25061102 #FOAvip The neural crest is a multi-potent, highly migratory cell population that gives rise to diverse cell types, including melanocytes. Factors regulating the development of the neural crest and emigration of its cells are likely to influence melanoma metastasis. The transcription factor FOXD3 plays an essential role in pre-migratory neural crest development and has been implicated in melanoma cell dormancy and response to therapeutics. FOXD3 is down-regulated during migration of the melanocyte lineage from the neural crest, and our previous work supports a role for FOXD3 in suppressing melanoma cell migration and invasion. Alternatively, TWIST1 is known to have pro-migratory and pro-invasive roles in a number of cancers, including melanoma. Utilizing ChIP-seq analysis, TWIST1 was identified as a potential transcriptional target of FOXD3. Mechanistically, FOXD3 directly binds to regions of the TWIST1 gene locus, leading to transcriptional repression of TWIST1 in human mutant BRAF melanoma cells. Additionally, depletion of endogenous FOXD3 promotes up-regulation of TWIST1 transcript and protein. Finally, FOXD3 expression leads to a significant decrease in cell migration that can be efficiently reversed by the overexpression of TWIST1. These findings uncover the novel interplay between FOXD3 and TWIST1, which is likely to be important in the melanoma metastatic cascade. Twit Text FOAVip FOXD3 Modulates Migration Through Direct Transcriptional Repression of TWIST1 in melanoma ????Mol Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=25061102 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25061102 #FOAvip English Wikipedia <ref>{{Cite pmid|25061102}}</ref> FOXD3 Modulates Migration Through Direct Transcriptional Repression of TWIST1 in melanoma #MMPMID25061102 Weiss MB; Abel EV; Dadpey N; Aplin AE Mol Cancer Res 2014[Sep]; 12 (9): 1314-23 PMID25061102show ga The neural crest is a multi-potent, highly migratory cell population that gives rise to diverse cell types, including melanocytes. Factors regulating the development of the neural crest and emigration of its cells are likely to influence melanoma metastasis. The transcription factor FOXD3 plays an essential role in pre-migratory neural crest development and has been implicated in melanoma cell dormancy and response to therapeutics. FOXD3 is down-regulated during migration of the melanocyte lineage from the neural crest, and our previous work supports a role for FOXD3 in suppressing melanoma cell migration and invasion. Alternatively, TWIST1 is known to have pro-migratory and pro-invasive roles in a number of cancers, including melanoma. Utilizing ChIP-seq analysis, TWIST1 was identified as a potential transcriptional target of FOXD3. Mechanistically, FOXD3 directly binds to regions of the TWIST1 gene locus, leading to transcriptional repression of TWIST1 in human mutant BRAF melanoma cells. Additionally, depletion of endogenous FOXD3 promotes up-regulation of TWIST1 transcript and protein. Finally, FOXD3 expression leads to a significant decrease in cell migration that can be efficiently reversed by the overexpression of TWIST1. These findings uncover the novel interplay between FOXD3 and TWIST1, which is likely to be important in the melanoma metastatic cascade. äFOXD3 Modulates Migration Through Direct Transcriptional Repression of(epmc).pdf DeepDyve Pubget Overpricing