Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1158/1541-7786.MCR-14-0131 http://scihub22266oqcxt.onion/10.1158/1541-7786.MCR-14-0131 C4163531!4163531!24807918     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Cancer+Res 2014 ; 12 (9): 1195-204 Nephropedia Template TP {{tp|p=24807918|t=2014. Emerging functions of SRSF1, splicing factor and oncoprotein, in RNA metabolism and cancer |pdf=|usr=}}{{24807918}} gab.com Text Emerging functions of SRSF1, splicing factor and oncoprotein, in RNA metabolism and cancer JO: Mol Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=24807918 #FOAvip Serine/Arginine Splicing Factor 1 (SRSF1) is the archetype member of the SR protein family of splicing regulators. Since its discovery, over two decades ago, SRSF1 has been repeatedly surprising and intriguing investigators by the plethora of complex biological pathways it regulates. These include several key aspects of mRNA metabolism, such as mRNA splicing, stability, and translation, as well as other mRNA-independent processes, such as miRNA (miR) processing, protein sumoylation, and the nucleolar-stress response. In this review, the structural features of SRSF1 are discussed as they relate to the intricate mechanism of splicing and the multiplicity of functions it performs. Similarly, a list of relevant alternatively spliced transcripts and SRSF1 interacting proteins is provided. Finally, emphasis is given to the deleterious consequences of overexpression of the SRSF1 proto-oncogene in human cancers, and the complex mechanisms and pathways underlying SRSF1-mediated transformation. The accumulated knowledge about SRSF1 provides critical insight into the integral role it plays in maintaining cellular homeostasis, and suggests new targets for anti-cancer therapy. Twit Text FOAVip Emerging functions of SRSF1, splicing factor and oncoprotein, in RNA metabolism and cancer ????Mol Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=24807918 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24807918 #FOAvip English Wikipedia <ref>{{Cite pmid|24807918}}</ref> Emerging functions of SRSF1, splicing factor and oncoprotein, in RNA metabolism and cancer #MMPMID24807918 Das S; Krainer AR Mol Cancer Res 2014[Sep]; 12 (9): 1195-204 PMID24807918show ga Serine/Arginine Splicing Factor 1 (SRSF1) is the archetype member of the SR protein family of splicing regulators. Since its discovery, over two decades ago, SRSF1 has been repeatedly surprising and intriguing investigators by the plethora of complex biological pathways it regulates. These include several key aspects of mRNA metabolism, such as mRNA splicing, stability, and translation, as well as other mRNA-independent processes, such as miRNA (miR) processing, protein sumoylation, and the nucleolar-stress response. In this review, the structural features of SRSF1 are discussed as they relate to the intricate mechanism of splicing and the multiplicity of functions it performs. Similarly, a list of relevant alternatively spliced transcripts and SRSF1 interacting proteins is provided. Finally, emphasis is given to the deleterious consequences of overexpression of the SRSF1 proto-oncogene in human cancers, and the complex mechanisms and pathways underlying SRSF1-mediated transformation. The accumulated knowledge about SRSF1 provides critical insight into the integral role it plays in maintaining cellular homeostasis, and suggests new targets for anti-cancer therapy. äEmerging functions of SRSF1, splicing factor and oncoprotein, in RNA m(epmc).pdf DeepDyve Pubget Overpricing