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10.1158/1541-7786.MCR-14-0080 http://scihub22266oqcxt.onion/10.1158/1541-7786.MCR-14-0080 C4163521!4163521!25033841     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Cancer+Res 2014 ; 12 (9): 1283-91 Nephropedia Template TP {{tp|p=25033841|t=2014. Extrinsic Apoptosis is Impeded by Direct Binding of the APL Fusion Protein NPM-RAR to TRADD |pdf=|usr=}}{{25033841}} gab.com Text Extrinsic Apoptosis is Impeded by Direct Binding of the APL Fusion Protein NPM-RAR to TRADD JO: Mol Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=25033841 #FOAvip A subset of acute promyelocytic leukemia (APL) cases have been characterized by the t(5;17)(q35;q21) translocation variant which fuses nucleophosmin (NPM) to retinoic acid receptor alpha (RARA). The resultant NPM-RAR fusion protein blocks myeloid differentiation, and leads to a leukemic phenotype similar to that caused by the t(15;17)(q22;q21) PML-RAR fusion. The contribution of the N-terminal 117 amino acids of NPM contained within NPM-RAR has not been well studied. As a molecular chaperone, NPM interacts with a variety of proteins implicated in leukemogenesis. Therefore, a proteomic analysis was conducted to identify novel NPM-RAR associated proteins. Tumor necrosis factor receptor type 1-associated DEATH domain protein (TRADD) was identified as a relevant binding partner for NPM-RAR. This interaction was validated by co-precipitation and co-localization analysis. Biological assessment found that NPM-RAR expression impaired TNF-induced signaling through TRADD, blunting TNF-mediated activation of caspase 3 (CASP3) and caspase 8 (CASP8), to ultimately block apoptosis.Implications: This study identifies a novel mechanism through which NPM-RAR impacts leukemogenesis. Twit Text FOAVip Extrinsic Apoptosis is Impeded by Direct Binding of the APL Fusion Protein NPM-RAR to TRADD ????Mol Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=25033841 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25033841 #FOAvip English Wikipedia <ref>{{Cite pmid|25033841}}</ref> Extrinsic Apoptosis is Impeded by Direct Binding of the APL Fusion Protein NPM-RAR to TRADD #MMPMID25033841 Chattopadhyay A; Hood BL; Conrads TP; Redner RL Mol Cancer Res 2014[Sep]; 12 (9): 1283-91 PMID25033841show ga A subset of acute promyelocytic leukemia (APL) cases have been characterized by the t(5;17)(q35;q21) translocation variant which fuses nucleophosmin (NPM) to retinoic acid receptor alpha (RARA). The resultant NPM-RAR fusion protein blocks myeloid differentiation, and leads to a leukemic phenotype similar to that caused by the t(15;17)(q22;q21) PML-RAR fusion. The contribution of the N-terminal 117 amino acids of NPM contained within NPM-RAR has not been well studied. As a molecular chaperone, NPM interacts with a variety of proteins implicated in leukemogenesis. Therefore, a proteomic analysis was conducted to identify novel NPM-RAR associated proteins. Tumor necrosis factor receptor type 1-associated DEATH domain protein (TRADD) was identified as a relevant binding partner for NPM-RAR. This interaction was validated by co-precipitation and co-localization analysis. Biological assessment found that NPM-RAR expression impaired TNF-induced signaling through TRADD, blunting TNF-mediated activation of caspase 3 (CASP3) and caspase 8 (CASP8), to ultimately block apoptosis.Implications: This study identifies a novel mechanism through which NPM-RAR impacts leukemogenesis. äExtrinsic Apoptosis is Impeded by Direct Binding of the APL Fusion Pro(epmc).pdf DeepDyve Pubget Overpricing