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10.1016/j.semnephrol.2014.06.003

http://scihub22266oqcxt.onion/10.1016/j.semnephrol.2014.06.003
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C4163195!4163195!25217265
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suck abstract from ncbi


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pmid25217265      Semin+Nephrol 2014 ; 34 (4): 365-73
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  • ENDOTHELIAL PROGENITOR CELLS: FROM SENESCENCE TO REJUVENATION #MMPMID25217265
  • Goligorsky MS
  • Semin Nephrol 2014[Jul]; 34 (4): 365-73 PMID25217265show ga
  • Discovered more than 15 years ago, endothelial progenitor cells attract both basic and translational researchers. It has become clear that they represent a heterogeneous population of endothelial colony forming cells, early or late outgrowth endothelial cells, or blood outgrowth endothelial cells, each characterized by differing proliferative and regenerative capacity. Scattered within the vascular wall, these cells participate in angiogenesis and vasculogenesis and support regeneration of epithelial cells. There is growing evidence that this cell population is impaired during the course of chronic cardiovascular and kidney disease when it undergoes premature senescence and loss of specialized functions. Senescence-associated secretory products released by such cells can affect the neighboring cells and further exacerbate their regenerative capacity. For those reasons adoptive transfer of endothelial progenitor cells is being used in more than 150 on-going clinical trials in diverse cardiovascular diseases. There is emergence of attempts to rejuvenate this cell population either ex vivo or in situ. The progress in this field is paramount to regenerate the injured kidney.
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