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10.1016/j.brainres.2014.03.003

http://scihub22266oqcxt.onion/10.1016/j.brainres.2014.03.003
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C4163134!4163134!24631951
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suck abstract from ncbi


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pmid24631951      Brain+Res 2014 ; ä (ä): 105-15
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  • RNA Metabolism in the Pathogenesis of Parkinson?s Disease #MMPMID24631951
  • Lu B; Gehrke S; Wu Z
  • Brain Res 2014[Oct]; ä (ä): 105-15 PMID24631951show ga
  • Neurodegenerative diseases such as Parkinson?s disease are progressive disorders of the nervous system that affect the function and maintenance of specific neuronal populations. While most disease cases are sporadic with no known cause, a small percentage of disease cases is caused by inherited genetic mutations. The identification of genes associated with the familial forms of the diseases and subsequent studies of proteins encoded by the disease genes in cellular or animals models have offered much-needed insights into the molecular and cellular mechanisms underlying disease pathogenesis. Recent studies of the familial Parkinson?s disease genes have emphasized the importance of RNA metabolism, particularly mRNA translation, in the disease process. It is anticipated that continued studies on the role of RNA metabolism in Parkinson?s disease will offer unifying mechanisms for understanding the cause of neuronal dysfunction and degeneration and facilitate the development of novel and rational strategies for treating this debilitating disease.
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