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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Thromb+Haemost
2014 ; 12
(9
): 1455-60
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Serum 25-hydroxyvitamin D and risk of venous thromboembolism: the Atherosclerosis
Risk in Communities (ARIC) Study
#MMPMID25039645
Folsom AR
; Roetker NS
; Rosamond WD
; Heckbert SR
; Basu S
; Cushman M
; Lutsey PL
J Thromb Haemost
2014[Sep]; 12
(9
): 1455-60
PMID25039645
show ga
BACKGROUND: Some evidence suggests that an inadequate vitamin D level may
increase the risk for atherosclerotic cardiovascular disease. Whether a low
vitamin D level plays a role in venous thromboembolism (VTE), that is, venous
thrombosis and pulmonary embolism, is largely unexplored. OBJECTIVES: We tested
prospectively, in the Atherosclerosis Risk in Communities (ARIC) cohort, whether
the serum level of 25-hydroxyvitamin D (25[OH]D) is inversely associated with VTE
incidence, and whether it partly explains the African American excess of VTE in
the ARIC Study. PATIENTS AND METHODS: We measured 25(OH)D by using mass
spectroscopy in stored samples of 12 752 ARIC Study participants, and followed
them over a median of 19.7 years (1990-1992 to 2011) for the incidence of VTE
(n = 537). RESULTS: The seasonally adjusted 25(OH)D level was not associated with
VTE incidence. In a model adjusted for age, race, sex, hormone replacement
therapy, and body mass index, the hazard ratios of VTE across 25(OH)D quintiles 5
(high) to 1 (low) were: 1 (ref.), 0.84 (95% confidence interval [CI] 0.65-1.08),
0.88 (95% CI 0.68-1.13), 1.04 (95% CI 0.78-1.38), and 0.90 (95% CI 0.64-1.27).
The lowest 25(OH)D quintile contained 59% African Americans, whereas the highest
quintile contained 7% African Americans. However, lower 25(OH)D levels explained
little of the 63% greater VTE risk of African Americans over whites in this
cohort. CONCLUSIONS: A low 25(OH)D level was not a risk factor for VTE in this
prospective study. However, the totality of the literature (three studies)
suggests that a low 25(OH)D level might modestly increase VTE risk in whites, but
this needs further confirmation.