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10.1111/jth.12665

http://scihub22266oqcxt.onion/10.1111/jth.12665
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suck abstract from ncbi


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pmid25039645
      J+Thromb+Haemost 2014 ; 12 (9 ): 1455-60
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  • Serum 25-hydroxyvitamin D and risk of venous thromboembolism: the Atherosclerosis Risk in Communities (ARIC) Study #MMPMID25039645
  • Folsom AR ; Roetker NS ; Rosamond WD ; Heckbert SR ; Basu S ; Cushman M ; Lutsey PL
  • J Thromb Haemost 2014[Sep]; 12 (9 ): 1455-60 PMID25039645 show ga
  • BACKGROUND: Some evidence suggests that an inadequate vitamin D level may increase the risk for atherosclerotic cardiovascular disease. Whether a low vitamin D level plays a role in venous thromboembolism (VTE), that is, venous thrombosis and pulmonary embolism, is largely unexplored. OBJECTIVES: We tested prospectively, in the Atherosclerosis Risk in Communities (ARIC) cohort, whether the serum level of 25-hydroxyvitamin D (25[OH]D) is inversely associated with VTE incidence, and whether it partly explains the African American excess of VTE in the ARIC Study. PATIENTS AND METHODS: We measured 25(OH)D by using mass spectroscopy in stored samples of 12 752 ARIC Study participants, and followed them over a median of 19.7 years (1990-1992 to 2011) for the incidence of VTE (n = 537). RESULTS: The seasonally adjusted 25(OH)D level was not associated with VTE incidence. In a model adjusted for age, race, sex, hormone replacement therapy, and body mass index, the hazard ratios of VTE across 25(OH)D quintiles 5 (high) to 1 (low) were: 1 (ref.), 0.84 (95% confidence interval [CI] 0.65-1.08), 0.88 (95% CI 0.68-1.13), 1.04 (95% CI 0.78-1.38), and 0.90 (95% CI 0.64-1.27). The lowest 25(OH)D quintile contained 59% African Americans, whereas the highest quintile contained 7% African Americans. However, lower 25(OH)D levels explained little of the 63% greater VTE risk of African Americans over whites in this cohort. CONCLUSIONS: A low 25(OH)D level was not a risk factor for VTE in this prospective study. However, the totality of the literature (three studies) suggests that a low 25(OH)D level might modestly increase VTE risk in whites, but this needs further confirmation.
  • |Atherosclerosis/*blood/ethnology [MESH]
  • |Black or African American [MESH]
  • |Female [MESH]
  • |Humans [MESH]
  • |Incidence [MESH]
  • |Male [MESH]
  • |Mass Spectrometry [MESH]
  • |Middle Aged [MESH]
  • |Proportional Hazards Models [MESH]
  • |Prospective Studies [MESH]
  • |Pulmonary Embolism/*blood/ethnology [MESH]
  • |Risk Factors [MESH]
  • |Seasons [MESH]
  • |Treatment Outcome [MESH]
  • |United States [MESH]
  • |Venous Thrombosis/*blood/ethnology [MESH]


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