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10.1161/HYPERTENSIONAHA.114.03848 http://scihub22266oqcxt.onion/10.1161/HYPERTENSIONAHA.114.03848 C4162750!4162750 !25001273     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25001273 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Hypertension 2014 ; 64 (4 ): 852-9 Nephropedia Template TP {{tp|p=25001273 |t=2014. Vasopressin in preeclampsia: a novel very early human pregnancy biomarker and clinically relevant mouse model |pdf=|usr=}}{{25001273 }} gab.com Text Vasopressin in preeclampsia: a novel very early human pregnancy biomarker and clinically relevant mouse model JO: Hypertension http://www.kidney.de/pget.php?&tw=1&pmid=25001273 #FOAvip Preeclampsia, a cardiovascular disorder of late pregnancy, is characterized as a low-renin hypertensive state relative to normotensive pregnancy. Because other nonpregnant low-renin hypertensive disorders often exhibit and are occasionally dependent on elevated arginine vasopressin (AVP) secretion, we hypothesized a possible use for plasma AVP measurements in the prediction of preeclampsia. Copeptin is an inert prosegment of AVP that is secreted in a 1:1 molar ratio and exhibits a substantially longer biological half-life compared with AVP, rendering it a clinically useful biomarker of AVP secretion. Copeptin was measured throughout pregnancy in maternal plasma from preeclamptic and control women. Maternal plasma copeptin was significantly higher throughout preeclamptic pregnancies versus control pregnancies. While controlling for clinically significant confounders (age, body mass index, chronic essential hypertension, twin gestation, diabetes mellitus, and history of preeclampsia) using multivariate regression, the association of higher copeptin concentration and the development of preeclampsia remained significant. Receiver operating characteristic analyses reveal that as early as the sixth week of gestation, elevated maternal plasma copeptin concentration is a highly significant predictor of preeclampsia throughout pregnancy. Finally, chronic infusion of AVP during pregnancy (24 ng per hour) is sufficient to phenocopy preeclampsia in C57BL/6J mice, causing pregnancy-specific hypertension, renal glomerular endotheliosis, proteinuria, and intrauterine growth restriction. These data implicate AVP release as a novel predictive biomarker for preeclampsia very early in pregnancy, identify chronic AVP infusion as a novel and clinically relevant model of preeclampsia in mice, and are consistent with a potential causative role for AVP in preeclampsia in humans. Twit Text FOAVip Vasopressin in preeclampsia: a novel very early human pregnancy biomarker and clinically relevant mouse model ????Hypertension http://www.kidney.de/pget.php?&tw=1&pmid=25001273 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25001273 #FOAvip English Wikipedia <ref>{{Cite pmid|25001273 }}</ref> Vasopressin in preeclampsia: a novel very early human pregnancy biomarker and clinically relevant mouse model #MMPMID25001273 Santillan MK ; Santillan DA ; Scroggins SM ; Min JY ; Sandgren JA ; Pearson NA ; Leslie KK ; Hunter SK ; Zamba GK ; Gibson-Corley KN ; Grobe JL Hypertension 2014[Oct]; 64 (4 ): 852-9 PMID25001273 show ga Preeclampsia, a cardiovascular disorder of late pregnancy, is characterized as a low-renin hypertensive state relative to normotensive pregnancy. Because other nonpregnant low-renin hypertensive disorders often exhibit and are occasionally dependent on elevated arginine vasopressin (AVP) secretion, we hypothesized a possible use for plasma AVP measurements in the prediction of preeclampsia. Copeptin is an inert prosegment of AVP that is secreted in a 1:1 molar ratio and exhibits a substantially longer biological half-life compared with AVP, rendering it a clinically useful biomarker of AVP secretion. Copeptin was measured throughout pregnancy in maternal plasma from preeclamptic and control women. Maternal plasma copeptin was significantly higher throughout preeclamptic pregnancies versus control pregnancies. While controlling for clinically significant confounders (age, body mass index, chronic essential hypertension, twin gestation, diabetes mellitus, and history of preeclampsia) using multivariate regression, the association of higher copeptin concentration and the development of preeclampsia remained significant. Receiver operating characteristic analyses reveal that as early as the sixth week of gestation, elevated maternal plasma copeptin concentration is a highly significant predictor of preeclampsia throughout pregnancy. Finally, chronic infusion of AVP during pregnancy (24 ng per hour) is sufficient to phenocopy preeclampsia in C57BL/6J mice, causing pregnancy-specific hypertension, renal glomerular endotheliosis, proteinuria, and intrauterine growth restriction. These data implicate AVP release as a novel predictive biomarker for preeclampsia very early in pregnancy, identify chronic AVP infusion as a novel and clinically relevant model of preeclampsia in mice, and are consistent with a potential causative role for AVP in preeclampsia in humans. |*Early Diagnosis [MESH] |Adult [MESH] |Animals [MESH] |Arginine Vasopressin/administration & dosage/blood [MESH] |Biomarkers/*blood [MESH] |Blood Pressure/drug effects/physiology [MESH] |Disease Models, Animal [MESH] |Endothelium, Vascular/drug effects/pathology [MESH] |Female [MESH] |Glycopeptides/blood [MESH] |Humans [MESH] |Hypertension/blood/physiopathology [MESH] |Kidney Glomerulus/drug effects/pathology [MESH] |Male [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Pre-Eclampsia/*blood/*diagnosis/physiopathology [MESH] |Pregnancy [MESH] |Proteinuria/blood [MESH] |ROC Curve [MESH] |Time Factors [MESH]Vasopressin in preeclampsia: a novel very early human pregnancy biomar(epmc).pdf DeepDyve Pubget Overpricing