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10.1074/jbc.M114.552570 http://scihub22266oqcxt.onion/10.1074/jbc.M114.552570 C4162179!4162179 !25070891     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25070891 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Biol+Chem 2014 ; 289 (37 ): 25774-82 Nephropedia Template TP {{tp|p=25070891 |t=2014. The Fanconi anemia proteins FANCD2 and FANCJ interact and regulate each other s chromatin localization |pdf=|usr=}}{{25070891 }} gab.com Text The Fanconi anemia proteins FANCD2 and FANCJ interact and regulate each other s chromatin localization JO: J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=25070891 #FOAvip Fanconi anemia is a genetic disease resulting in bone marrow failure, birth defects, and cancer that is thought to encompass a defect in maintenance of genomic stability. Mutations in 16 genes (FANCA, B, C, D1, D2, E, F, G, I, J, L, M, N, O, P, and Q) have been identified in patients, with the Fanconi anemia subtype J (FA-J) resulting from homozygous mutations in the FANCJ gene. Here, we describe the direct interaction of FANCD2 with FANCJ. We demonstrate the interaction of FANCD2 and FANCJ in vivo and in vitro by immunoprecipitation in crude cell lysates and from fractions after gel filtration and with baculovirally expressed proteins. Mutation of the monoubiquitination site of FANCD2 (K561R) preserves interaction with FANCJ constitutively in a manner that impedes proper chromatin localization of FANCJ. FANCJ is necessary for FANCD2 chromatin loading and focus formation in response to mitomycin C treatment. Our results suggest not only that FANCD2 regulates FANCJ chromatin localization but also that FANCJ is necessary for efficient loading of FANCD2 onto chromatin following DNA damage caused by mitomycin C treatment. Twit Text FOAVip The Fanconi anemia proteins FANCD2 and FANCJ interact and regulate each other s chromatin localization ????J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=25070891 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25070891 #FOAvip English Wikipedia <ref>{{Cite pmid|25070891 }}</ref> The Fanconi anemia proteins FANCD2 and FANCJ interact and regulate each other s chromatin localization #MMPMID25070891 Chen X ; Wilson JB ; McChesney P ; Williams SA ; Kwon Y ; Longerich S ; Marriott AS ; Sung P ; Jones NJ ; Kupfer GM J Biol Chem 2014[Sep]; 289 (37 ): 25774-82 PMID25070891 show ga Fanconi anemia is a genetic disease resulting in bone marrow failure, birth defects, and cancer that is thought to encompass a defect in maintenance of genomic stability. Mutations in 16 genes (FANCA, B, C, D1, D2, E, F, G, I, J, L, M, N, O, P, and Q) have been identified in patients, with the Fanconi anemia subtype J (FA-J) resulting from homozygous mutations in the FANCJ gene. Here, we describe the direct interaction of FANCD2 with FANCJ. We demonstrate the interaction of FANCD2 and FANCJ in vivo and in vitro by immunoprecipitation in crude cell lysates and from fractions after gel filtration and with baculovirally expressed proteins. Mutation of the monoubiquitination site of FANCD2 (K561R) preserves interaction with FANCJ constitutively in a manner that impedes proper chromatin localization of FANCJ. FANCJ is necessary for FANCD2 chromatin loading and focus formation in response to mitomycin C treatment. Our results suggest not only that FANCD2 regulates FANCJ chromatin localization but also that FANCJ is necessary for efficient loading of FANCD2 onto chromatin following DNA damage caused by mitomycin C treatment. |*Protein Binding [MESH] |Basic-Leucine Zipper Transcription Factors/genetics/*metabolism [MESH] |Chromatin/*genetics [MESH] |DNA Damage/genetics [MESH] |DNA Repair/genetics [MESH] |DNA-Binding Proteins/genetics [MESH] |Fanconi Anemia Complementation Group D2 Protein/genetics/*metabolism [MESH] |Fanconi Anemia Complementation Group Proteins/genetics/*metabolism [MESH] |Fanconi Anemia/*genetics/metabolism/pathology [MESH] |Genomic Instability [MESH] |Humans [MESH]The Fanconi anemia proteins FANCD2 and FANCJ interact and regulate eac(epmc).pdf DeepDyve Pubget Overpricing