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10.1074/jbc.M114.591487

http://scihub22266oqcxt.onion/10.1074/jbc.M114.591487
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C4162162!4162162!25063806
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suck abstract from ncbi


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pmid25063806      J+Biol+Chem 2014 ; 289 (37): 25571-80
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  • The N- and C-terminal Domains of Tomosyn Play Distinct Roles in Soluble N-Ethylmaleimide-sensitive Factor Attachment Protein Receptor Binding and Fusion Regulation* #MMPMID25063806
  • Yu H; Rathore SS; Gulbranson DR; Shen J
  • J Biol Chem 2014[Sep]; 289 (37): 25571-80 PMID25063806show ga
  • Background: Tomosyn regulates vesicle fusion but its mechanism remains incompletely understood.Results: Tomosyn uses its C-terminal domain to arrest SNARE-dependent fusion reactions, whereas its N-terminal domain is required for syntaxin interaction.Conclusion: We have uncovered distinct roles of the N- and C-terminal domains of tomosyn in SNARE binding and fusion regulation.Significance: Our findings shed light upon vesicle transport in the cell.
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