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10.1182/blood-2014-02-555128 http://scihub22266oqcxt.onion/10.1182/blood-2014-02-555128 C4162113!4162113 !25030062     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25030062 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Blood 2014 ; 124 (11 ): 1832-42 Nephropedia Template TP {{tp|p=25030062 |t=2014. Autologous apoptotic cells preceding transplantation enhance survival in lethal murine graft-versus-host models |pdf=|usr=}}{{25030062 }} gab.com Text Autologous apoptotic cells preceding transplantation enhance survival in lethal murine graft-versus-host models JO: Blood http://www.kidney.de/pget.php?&tw=1&pmid=25030062 #FOAvip Acute graft-versus-host disease (GVHD) is induced by alloreactivity of donor T cells toward host antigens presented on antigen-presenting cells (APCs). Apoptotic cells are capable of inducing tolerance by altering APC maturation. Apoptosis can be induced by extracorporeal photopheresis (ECP). We demonstrate that the use of ECP as a prophylaxis prior to conditioning significantly improves survival (P < .0001) after bone marrow transplantation (BMT) by inhibiting the initiation phase of acute GVHD in a murine BMT model. ECP-treated autologous splenocytes resulted in immune tolerance in the host, including reduced dendritic cell activation with decreased nuclear factor-?B engagement, increased regulatory T-cell (Treg) numbers with enhanced expression of cytolytic T lymphocyte-associated antigen 4, potentiating their suppressive function. The protective effect required host production of interleukin-10 and host Tregs. Conventional T cells that entered this tolerant environment experienced reduced proliferation, as well as a reduction of tissue homing and expression of activation markers. The induction of this tolerant state by ECP was obviated by cotreatment with lipopolysaccharide, suggesting that the inflammatory state of the recipient prior to treatment would play a role in potential clinical translation. The use of prophylactic ECP may provide an alternative and safe method for immunosuppression in the bone marrow transplant setting. Twit Text FOAVip Autologous apoptotic cells preceding transplantation enhance survival in lethal murine graft-versus-host models ????Blood http://www.kidney.de/pget.php?&tw=1&pmid=25030062 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25030062 #FOAvip English Wikipedia <ref>{{Cite pmid|25030062 }}</ref> Autologous apoptotic cells preceding transplantation enhance survival in lethal murine graft-versus-host models #MMPMID25030062 Florek M ; Sega EI ; Leveson-Gower DB ; Baker J ; Müller AM ; Schneidawind D ; Meyer E ; Negrin RS Blood 2014[Sep]; 124 (11 ): 1832-42 PMID25030062 show ga Acute graft-versus-host disease (GVHD) is induced by alloreactivity of donor T cells toward host antigens presented on antigen-presenting cells (APCs). Apoptotic cells are capable of inducing tolerance by altering APC maturation. Apoptosis can be induced by extracorporeal photopheresis (ECP). We demonstrate that the use of ECP as a prophylaxis prior to conditioning significantly improves survival (P < .0001) after bone marrow transplantation (BMT) by inhibiting the initiation phase of acute GVHD in a murine BMT model. ECP-treated autologous splenocytes resulted in immune tolerance in the host, including reduced dendritic cell activation with decreased nuclear factor-?B engagement, increased regulatory T-cell (Treg) numbers with enhanced expression of cytolytic T lymphocyte-associated antigen 4, potentiating their suppressive function. The protective effect required host production of interleukin-10 and host Tregs. Conventional T cells that entered this tolerant environment experienced reduced proliferation, as well as a reduction of tissue homing and expression of activation markers. The induction of this tolerant state by ECP was obviated by cotreatment with lipopolysaccharide, suggesting that the inflammatory state of the recipient prior to treatment would play a role in potential clinical translation. The use of prophylactic ECP may provide an alternative and safe method for immunosuppression in the bone marrow transplant setting. |*Apoptosis [MESH] |*Immune Tolerance [MESH] |Animals [MESH] |Antigen-Presenting Cells/immunology/pathology/*transplantation [MESH] |Autografts [MESH] |Bone Marrow Transplantation [MESH] |Disease Models, Animal [MESH] |Graft vs Host Disease/genetics/immunology/pathology/*prevention & control [MESH] |Interleukin-10/genetics/immunology [MESH] |Mice [MESH] |Mice, Inbred AKR [MESH] |Mice, Inbred BALB C [MESH] |Mice, Knockout [MESH]Autologous apoptotic cells preceding transplantation enhance survival (epmc).pdf DeepDyve Pubget Overpricing