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10.1002/bies.201300123 http://scihub22266oqcxt.onion/10.1002/bies.201300123 C4162090!4162090 !24519896     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24519896 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Bioessays 2014 ; 36 (4 ): 346-52 Nephropedia Template TP {{tp|p=24519896 |t=2014. Beyond transcriptional silencing: is methylcytosine a widely conserved eukaryotic DNA elimination mechanism? |pdf=|usr=}}{{24519896 }} gab.com Text Beyond transcriptional silencing: is methylcytosine a widely conserved eukaryotic DNA elimination mechanism JO: Bioessays http://www.kidney.de/pget.php?&tw=1&pmid=24519896 #FOAvip Methylation of cytosine DNA residues is a well-studied epigenetic modification with important roles in formation of heterochromatic regions of the genome, and also in tissue-specific repression of transcription. However, we recently found that the ciliate Oxytricha uses methylcytosine in a novel DNA elimination pathway important for programmed genome restructuring. Remarkably, mounting evidence suggests that methylcytosine can play a dual role in ciliates, repressing gene expression during some life-stages and directing DNA elimination in others. In this essay, I describe these recent advances in the DNA methylation field and discuss whether this unexpected novel role for methylcytosine in DNA elimination might be more widely conserved in eukaryotic biology, particularly in apoptotic pathways. Twit Text FOAVip Beyond transcriptional silencing: is methylcytosine a widely conserved eukaryotic DNA elimination mechanism ????Bioessays http://www.kidney.de/pget.php?&tw=1&pmid=24519896 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24519896 #FOAvip English Wikipedia <ref>{{Cite pmid|24519896 }}</ref> Beyond transcriptional silencing: is methylcytosine a widely conserved eukaryotic DNA elimination mechanism? #MMPMID24519896 Bracht JR Bioessays 2014[Apr]; 36 (4 ): 346-52 PMID24519896 show ga Methylation of cytosine DNA residues is a well-studied epigenetic modification with important roles in formation of heterochromatic regions of the genome, and also in tissue-specific repression of transcription. However, we recently found that the ciliate Oxytricha uses methylcytosine in a novel DNA elimination pathway important for programmed genome restructuring. Remarkably, mounting evidence suggests that methylcytosine can play a dual role in ciliates, repressing gene expression during some life-stages and directing DNA elimination in others. In this essay, I describe these recent advances in the DNA methylation field and discuss whether this unexpected novel role for methylcytosine in DNA elimination might be more widely conserved in eukaryotic biology, particularly in apoptotic pathways. |*DNA Methylation [MESH] |*Gene Expression [MESH] |Ciliophora/genetics [MESH] |Cytosine/*metabolism [MESH] |DNA/*metabolism [MESH] |Epigenesis, Genetic [MESH] |Eukaryotic Cells/physiology [MESH] |Heterochromatin/genetics/metabolism [MESH] |Histones/metabolism [MESH] |Oxytricha/*genetics [MESH]Beyond transcriptional silencing: is methylcytosine a widely conserved(epmc).pdf DeepDyve Pubget Overpricing