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10.1039/c4ob01033g

http://scihub22266oqcxt.onion/10.1039/c4ob01033g
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suck abstract from ncbi


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pmid25119424
      Org+Biomol+Chem 2014 ; 12 (38 ): 7445-68
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  • Nitroso Diels-Alder (NDA) reaction as an efficient tool for the functionalization of diene-containing natural products #MMPMID25119424
  • Carosso S ; Miller MJ
  • Org Biomol Chem 2014[Oct]; 12 (38 ): 7445-68 PMID25119424 show ga
  • This review describes the use of nitroso Diels-Alder reactions for the functionalization of complex diene-containing natural products in order to generate libraries of compounds with potential biological activity. The application of this methodology to the structural modification of a series of natural products (thebaine, steroidal dienes, rapamycin, leucomycin, colchicine, isocolchicine and piperine) is discussed using relevant examples from the literature from 1973 onwards. The biological activity of the resulting compounds is also discussed. Additional comments are provided that evaluate the methodology as a useful tool in organic, bioorganic and medicinal chemistry.
  • |Biological Products/*chemical synthesis/*chemistry [MESH]
  • |Cycloaddition Reaction/*methods [MESH]
  • |Nitroso Compounds/*chemistry [MESH]


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