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10.1021/ml500255j http://scihub22266oqcxt.onion/10.1021/ml500255j C4160763!4160763!25221661     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       ACS+Med+Chem+Lett 2014 ; 5 (9): 1027-31 Nephropedia Template TP {{tp|p=25221661|t=2014. Synthesis of Novel Tylophorine Derivatives and Evaluation of Their Anti-Inflammatory Activity |pdf=|usr=}}{{25221661}} gab.com Text Synthesis of Novel Tylophorine Derivatives and Evaluation of Their Anti-Inflammatory Activity JO: ACS Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=25221661 #FOAvip We have previously demonstrated that DCB-3503, a tylophorine analogue, has an anti-inflammatory property in murine models for autoimmune diseases. However, its mechanism remains unknown. Here, we have synthesized 34 derivatives of DCB-3503 and investigated their effects on T cells differentiation and TNF-? production. Six derivatives (4, 9, 13, 19, 31, and 32) could significantly promote the expression of Foxp3. Among these, the IC50 of 31 and 32 was about 500 ?M. Eight analogues (1, 2, 4, 9, 12, 18, 19, and 21) showed anti-TNF-? effect in Raw 264.7 cells and murine splenocytes, of which 18 and 19 were most significant. Moreover, 31 and 18 showed a better activity and cell survival ratio when compared with DCB-3503 at various concentrations. In summary, we have demonstrated the anti-inflammatory characteristics of 34 novel tylophorine derivatives and discussed their structure?activity relationship in order to explore their therapeutic potentials for inflammatory diseases. Twit Text FOAVip Synthesis of Novel Tylophorine Derivatives and Evaluation of Their Anti-Inflammatory Activity ????ACS Med Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=25221661 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25221661 #FOAvip English Wikipedia <ref>{{Cite pmid|25221661}}</ref> Synthesis of Novel Tylophorine Derivatives and Evaluation of Their Anti-Inflammatory Activity #MMPMID25221661 Wen T; Wang Z; Meng X; Wu M; Li Y; Wu X; Zhao L; Wang P; Yin Z; Li-Ling J; Wang Q ACS Med Chem Lett 2014[Sep]; 5 (9): 1027-31 PMID25221661show ga We have previously demonstrated that DCB-3503, a tylophorine analogue, has an anti-inflammatory property in murine models for autoimmune diseases. However, its mechanism remains unknown. Here, we have synthesized 34 derivatives of DCB-3503 and investigated their effects on T cells differentiation and TNF-? production. Six derivatives (4, 9, 13, 19, 31, and 32) could significantly promote the expression of Foxp3. Among these, the IC50 of 31 and 32 was about 500 ?M. Eight analogues (1, 2, 4, 9, 12, 18, 19, and 21) showed anti-TNF-? effect in Raw 264.7 cells and murine splenocytes, of which 18 and 19 were most significant. Moreover, 31 and 18 showed a better activity and cell survival ratio when compared with DCB-3503 at various concentrations. In summary, we have demonstrated the anti-inflammatory characteristics of 34 novel tylophorine derivatives and discussed their structure?activity relationship in order to explore their therapeutic potentials for inflammatory diseases. äSynthesis of Novel Tylophorine Derivatives and Evaluation of Their Ant(epmc).pdf DeepDyve Pubget Overpricing