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10.1016/j.ccr.2014.07.014 http://scihub22266oqcxt.onion/10.1016/j.ccr.2014.07.014 C4160352!4160352!25155756     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cancer+Cell 2014 ; 26 (3): 319-30 Nephropedia Template TP {{tp|p=25155756|t=2014. The somatic genomic landscape of chromophobe renal cell carcinoma |pdf=|usr=}}{{25155756}} gab.com Text The somatic genomic landscape of chromophobe renal cell carcinoma JO: Cancer Cell http://www.kidney.de/pget.php?&tw=1&pmid=25155756 #FOAvip We describe the landscape of somatic genomic alterations of 66 chromophobe renal cell carcinomas (ChRCCs) based on multidimensional and comprehensive characterization, including mitochondrial DNA (mtDNA) and whole genome sequencing. The result is consistent that ChRCC originates from the distal nephron compared to other kidney cancers with more proximal origins. Combined mtDNA and gene expression analysis implicates changes in mitochondrial function as a component of the disease biology, while suggesting alternative roles for mtDNA mutations in cancers relying on oxidative phosphorylation. Genomic rearrangements lead to recurrent structural breakpoints within TERT promoter region, which correlates with highly elevated TERT expression and manifestation of kataegis, representing a mechanism of TERT up-regulation in cancer distinct from previously-observed amplifications and point mutations. Twit Text FOAVip The somatic genomic landscape of chromophobe renal cell carcinoma ????Cancer Cell http://www.kidney.de/pget.php?&tw=1&pmid=25155756 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25155756 #FOAvip English Wikipedia <ref>{{Cite pmid|25155756}}</ref> The somatic genomic landscape of chromophobe renal cell carcinoma #MMPMID25155756 Davis CF; Ricketts C; Wang M; Yang L; Cherniack AD; Shen H; Buhay C; Kang H; Kim SC; Fahey CC; Hacker KE; Bhanot G; Gordenin DA; Chu A; Gunaratne PH; Biehl M; Seth S; Kaipparettu BA; Bristow CA; Donehower LA; Wallen EM; Smith AB; Tickoo SK; Tamboli P; Reuter V; Schmidt LS; Hsieh JJ; Choueiri TK; Hakimi AA; Chin L; Meyerson M; Kucherlapati R; Park WY; Robertson AG; Laird PW; Henske EP; Kwiatkowski DJ; Park PJ; Morgan M; Shuch B; Muzny D; Wheeler DA; Linehan WM; Gibbs RA; Rathmell WK; Creighton CJ Cancer Cell 2014[Sep]; 26 (3): 319-30 PMID25155756show ga We describe the landscape of somatic genomic alterations of 66 chromophobe renal cell carcinomas (ChRCCs) based on multidimensional and comprehensive characterization, including mitochondrial DNA (mtDNA) and whole genome sequencing. The result is consistent that ChRCC originates from the distal nephron compared to other kidney cancers with more proximal origins. Combined mtDNA and gene expression analysis implicates changes in mitochondrial function as a component of the disease biology, while suggesting alternative roles for mtDNA mutations in cancers relying on oxidative phosphorylation. Genomic rearrangements lead to recurrent structural breakpoints within TERT promoter region, which correlates with highly elevated TERT expression and manifestation of kataegis, representing a mechanism of TERT up-regulation in cancer distinct from previously-observed amplifications and point mutations. äThe somatic genomic landscape of chromophobe renal cell carcinoma (epmc).pdf DeepDyve Pubget Overpricing