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10.2217/epi.14.22 http://scihub22266oqcxt.onion/10.2217/epi.14.22 C4159956!4159956!25111486     free     free     free       Epigenomics 2014 ; 6 (3): 329-39 Nephropedia Template TP {{tp|p=25111486|t=2014. Functions of SAGA in development and disease |pdf=|usr=}}{{25111486}} gab.com Text Functions of SAGA in development and disease JO: Epigenomics http://www.kidney.de/pget.php?&tw=1&pmid=25111486 #FOAvip Precise regulation of gene expression programs during embryo development requires cooperation between transcriptional factors and histone-modifying enzymes, such as the Gcn5 histone acetyltransferase. Gcn5 functions within a multi-subunit complex, called SAGA, that is recruited to specific genes through interactions with sequence-specific DNA-binding proteins to aid in gene activation. Although the transcriptional programs regulated by SAGA in embryos are not well defined, deletion of either Gcn5 or USP22, the catalytic subunit of a deubiquitinase module in SAGA, leads to early embryonic lethality. Here, we review the known functions of Gcn5, USP22 and associated proteins during development and discuss how these functions might be related to human disease states, including cancer and neurodegenerative diseases. Twit Text FOAVip Functions of SAGA in development and disease ????Epigenomics http://www.kidney.de/pget.php?&tw=1&pmid=25111486 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25111486 #FOAvip English Wikipedia <ref>{{Cite pmid|25111486}}</ref> Functions of SAGA in development and disease #MMPMID25111486 Wang L; Dent SY Epigenomics 2014[Jun]; 6 (3): 329-39 PMID25111486show ga Precise regulation of gene expression programs during embryo development requires cooperation between transcriptional factors and histone-modifying enzymes, such as the Gcn5 histone acetyltransferase. Gcn5 functions within a multi-subunit complex, called SAGA, that is recruited to specific genes through interactions with sequence-specific DNA-binding proteins to aid in gene activation. Although the transcriptional programs regulated by SAGA in embryos are not well defined, deletion of either Gcn5 or USP22, the catalytic subunit of a deubiquitinase module in SAGA, leads to early embryonic lethality. Here, we review the known functions of Gcn5, USP22 and associated proteins during development and discuss how these functions might be related to human disease states, including cancer and neurodegenerative diseases. äFunctions of SAGA in development and disease (epmc).pdf DeepDyve Pubget Overpricing