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10.1016/j.ccr.2014.07.022 http://scihub22266oqcxt.onion/10.1016/j.ccr.2014.07.022 C4159622!4159622 !25203322     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25203322 &cmd=llinks): Failed to open stream: HTTP request failed! 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PKD1 phosphorylation-dependent degradation of SNAIL by SCF-FBXO11 regulates epithelial-mesenchymal transition and metastasis |pdf=|usr=}}{{25203322 }} gab.com Text PKD1 phosphorylation-dependent degradation of SNAIL by SCF-FBXO11 regulates epithelial-mesenchymal transition and metastasis JO: Cancer Cell http://www.kidney.de/pget.php?&tw=1&pmid=25203322 #FOAvip Metastatic dissemination is often initiated by the reactivation of an embryonic development program referred to as epithelial-mesenchymal transition (EMT). The transcription factor SNAIL promotes EMT and elicits associated pathological characteristics such as invasion, metastasis, and stemness. To better understand the posttranslational regulation of SNAIL, we performed a luciferase-based, genome-wide E3 ligase siRNA library screen and identified SCF-FBXO11 as an important E3 that targets SNAIL for ubiquitylation and degradation. Furthermore, we discovered that SNAIL degradation by FBXO11 is dependent on Ser-11 phosphorylation of SNAIL by protein kinase D1 (PKD1). FBXO11 blocks SNAIL-induced EMT, tumor initiation, and metastasis in multiple breast cancer models. These findings establish the PKD1-FBXO11-SNAIL axis as a mechanism of posttranslational regulation of EMT and cancer metastasis. Twit Text FOAVip PKD1 phosphorylation-dependent degradation of SNAIL by SCF-FBXO11 regulates epithelial-mesenchymal transition and metastasis ????Cancer Cell http://www.kidney.de/pget.php?&tw=1&pmid=25203322 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25203322 #FOAvip English Wikipedia <ref>{{Cite pmid|25203322 }}</ref> PKD1 phosphorylation-dependent degradation of SNAIL by SCF-FBXO11 regulates epithelial-mesenchymal transition and metastasis #MMPMID25203322 Zheng H ; Shen M ; Zha YL ; Li W ; Wei Y ; Blanco MA ; Ren G ; Zhou T ; Storz P ; Wang HY ; Kang Y Cancer Cell 2014[Sep]; 26 (3 ): 358-373 PMID25203322 show ga Metastatic dissemination is often initiated by the reactivation of an embryonic development program referred to as epithelial-mesenchymal transition (EMT). The transcription factor SNAIL promotes EMT and elicits associated pathological characteristics such as invasion, metastasis, and stemness. To better understand the posttranslational regulation of SNAIL, we performed a luciferase-based, genome-wide E3 ligase siRNA library screen and identified SCF-FBXO11 as an important E3 that targets SNAIL for ubiquitylation and degradation. Furthermore, we discovered that SNAIL degradation by FBXO11 is dependent on Ser-11 phosphorylation of SNAIL by protein kinase D1 (PKD1). FBXO11 blocks SNAIL-induced EMT, tumor initiation, and metastasis in multiple breast cancer models. These findings establish the PKD1-FBXO11-SNAIL axis as a mechanism of posttranslational regulation of EMT and cancer metastasis. |*Ubiquitination [MESH] |Animals [MESH] |Breast Neoplasms/*metabolism/mortality/pathology [MESH] |Cell Line, Tumor [MESH] |Disease-Free Survival [MESH] |Epithelial-Mesenchymal Transition [MESH] |F-Box Proteins/*metabolism [MESH] |Female [MESH] |Humans [MESH] |Kaplan-Meier Estimate [MESH] |Lung Neoplasms/*metabolism/mortality/secondary [MESH] |Mice [MESH] |Mice, Inbred BALB C [MESH] |Mice, Nude [MESH] |Neoplasm Transplantation [MESH] |Phosphorylation [MESH] |Protein Structure, Tertiary [MESH] |Protein-Arginine N-Methyltransferases/*metabolism [MESH] |Proteolysis [MESH] |SKP Cullin F-Box Protein Ligases/*metabolism [MESH] |Snail Family Transcription Factors [MESH] |TRPP Cation Channels/*physiology [MESH]PKD1 phosphorylation-dependent degradation of SNAIL by SCF-FBXO11 regu(epmc).pdf DeepDyve Pubget Overpricing