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10.1016/j.ccr.2014.07.023 http://scihub22266oqcxt.onion/10.1016/j.ccr.2014.07.023 C4159617!4159617!25203324     free     free     free       Cancer+Cell 2014 ; 26 (3): 390-401 Nephropedia Template TP {{tp|p=25203324|t=2014. Notch Activation as a Driver of Osteogenic Sarcoma |pdf=|usr=}}{{25203324}} gab.com Text Notch Activation as a Driver of Osteogenic Sarcoma JO: Cancer Cell http://www.kidney.de/pget.php?&tw=1&pmid=25203324 #FOAvip Osteogenic sarcoma (OS) is a deadly skeletal malignancy whose cause is unknown. We report here a mouse model of OS based on conditional expression of the intracellular domain of Notch1 (NICD). Expression of the NICD in immature osteoblasts was sufficient to drive the formation of bone tumors, including OS, with complete penetrance. These tumors display features of human OS, namely histopathology, cytogenetic complexity, and metastatic potential. We show that Notch activation combined with loss of p53 synergistically accelerates OS development in mice although p53-driven OS is not Rbpj-dependent, which demonstrates a dual dominance of the Notch oncogene and p53 mutation in the development of OS. Using this model, we also reveal the osteoblasts as the potential sources of OS. Twit Text FOAVip Notch Activation as a Driver of Osteogenic Sarcoma ????Cancer Cell http://www.kidney.de/pget.php?&tw=1&pmid=25203324 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25203324 #FOAvip English Wikipedia <ref>{{Cite pmid|25203324}}</ref> Notch Activation as a Driver of Osteogenic Sarcoma #MMPMID25203324 Tao J; Jiang MM; Jiang L; Salvo JS; Zeng HC; Dawson B; Bertin TK; Rao PH; Chen R; Donehower LA; Gannon F; Lee BH Cancer Cell 2014[Sep]; 26 (3): 390-401 PMID25203324show ga Osteogenic sarcoma (OS) is a deadly skeletal malignancy whose cause is unknown. We report here a mouse model of OS based on conditional expression of the intracellular domain of Notch1 (NICD). Expression of the NICD in immature osteoblasts was sufficient to drive the formation of bone tumors, including OS, with complete penetrance. These tumors display features of human OS, namely histopathology, cytogenetic complexity, and metastatic potential. We show that Notch activation combined with loss of p53 synergistically accelerates OS development in mice although p53-driven OS is not Rbpj-dependent, which demonstrates a dual dominance of the Notch oncogene and p53 mutation in the development of OS. Using this model, we also reveal the osteoblasts as the potential sources of OS. äNotch Activation as a Driver of Osteogenic Sarcoma (epmc).pdf DeepDyve Pubget Overpricing