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10.1039/c4cs00047a http://scihub22266oqcxt.onion/10.1039/c4cs00047a C4159426!4159426 !24676249     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24676249 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Chem+Soc+Rev 2014 ; 43 (19 ): 6859-69 Nephropedia Template TP {{tp|p=24676249 |t=2014. Chemical approaches to therapeutically target the metabolism and signaling of the endocannabinoid 2-AG and eicosanoids |pdf=|usr=}}{{24676249 }} gab.com Text Chemical approaches to therapeutically target the metabolism and signaling of the endocannabinoid 2-AG and eicosanoids JO: Chem Soc Rev http://www.kidney.de/pget.php?&tw=1&pmid=24676249 #FOAvip The endocannabinoid system, most popularly known as the target of the psychoactive component of marijuana, ?(9)-tetrahydrocannabinol (THC), is a signaling network that modulates a diverse range of physiological processes including nociception, behavior, cognitive function, appetite, metabolism, motor control, memory formation, and inflammation. While THC and its derivatives have garnered notoriety in the eyes of the public, the endocannabinoid system consists of two endogenous signaling lipids, 2-arachidonoylglycerol (2-AG) and N-arachidonoylethanolamine (anandamide), which activate cannabinoid receptors CB1 and CB2 in the nervous system and peripheral tissues. This review will focus on the recent efforts to chemically manipulate 2-AG signaling through the development of inhibitors of the 2-AG-synthesizing enzyme diacylglycerol lipase (DAGL) or the 2-AG-degrading enzyme monoacylglycerol lipase (MAGL), and assessing the therapeutic potential of DAGL and MAGL inhibitors in pain, inflammation, degenerative diseases, tissue injury, and cancer. Twit Text FOAVip Chemical approaches to therapeutically target the metabolism and signaling of the endocannabinoid 2-AG and eicosanoids ????Chem Soc Rev http://www.kidney.de/pget.php?&tw=1&pmid=24676249 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24676249 #FOAvip English Wikipedia <ref>{{Cite pmid|24676249 }}</ref> Chemical approaches to therapeutically target the metabolism and signaling of the endocannabinoid 2-AG and eicosanoids #MMPMID24676249 Kohnz RA ; Nomura DK Chem Soc Rev 2014[Oct]; 43 (19 ): 6859-69 PMID24676249 show ga The endocannabinoid system, most popularly known as the target of the psychoactive component of marijuana, ?(9)-tetrahydrocannabinol (THC), is a signaling network that modulates a diverse range of physiological processes including nociception, behavior, cognitive function, appetite, metabolism, motor control, memory formation, and inflammation. While THC and its derivatives have garnered notoriety in the eyes of the public, the endocannabinoid system consists of two endogenous signaling lipids, 2-arachidonoylglycerol (2-AG) and N-arachidonoylethanolamine (anandamide), which activate cannabinoid receptors CB1 and CB2 in the nervous system and peripheral tissues. This review will focus on the recent efforts to chemically manipulate 2-AG signaling through the development of inhibitors of the 2-AG-synthesizing enzyme diacylglycerol lipase (DAGL) or the 2-AG-degrading enzyme monoacylglycerol lipase (MAGL), and assessing the therapeutic potential of DAGL and MAGL inhibitors in pain, inflammation, degenerative diseases, tissue injury, and cancer. |Animals [MESH] |Arachidonic Acids/chemistry/*metabolism [MESH] |Dronabinol/chemistry/pharmacology/therapeutic use [MESH] |Eicosanoids/*metabolism [MESH] |Endocannabinoids/chemistry/*metabolism [MESH] |Enzyme Inhibitors/chemistry/pharmacology/therapeutic use [MESH] |Glycerides/chemistry/*metabolism [MESH] |Humans [MESH] |Lipoprotein Lipase/antagonists & inhibitors/metabolism [MESH] |Monoacylglycerol Lipases/antagonists & inhibitors/genetics/metabolism [MESH] |Mood Disorders/drug therapy/metabolism/pathology [MESH] |Neoplasms/drug therapy/metabolism/pathology [MESH] |Neurodegenerative Diseases/drug therapy/metabolism/pathology [MESH] |Pain/drug therapy/metabolism/pathology [MESH]Chemical approaches to therapeutically target the metabolism and signa(epmc).pdf DeepDyve Pubget Overpricing