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10.1007/s00011-014-0747-z http://scihub22266oqcxt.onion/10.1007/s00011-014-0747-z C4158117!4158117 !24915805     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24915805 &cmd=llinks): Failed to open stream: HTTP request failed! 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Effects of 5,14-HEDGE, a 20-HETE mimetic, on lipopolysaccharide-induced changes in MyD88/TAK1/IKK?/I?B-?/NF-?B pathway and circulating miR-150, miR-223, and miR-297 levels in a rat model of septic shock |pdf=|usr=}}{{24915805 }} gab.com Text Effects of 5,14-HEDGE, a 20-HETE mimetic, on lipopolysaccharide-induced changes in MyD88/TAK1/IKK /I B- /NF- B pathway and circulating miR-150, miR-223, and miR-297 levels in a rat model of septic shock JO: Inflamm Res http://www.kidney.de/pget.php?&tw=1&pmid=24915805 #FOAvip OBJECTIVES: We have previously demonstrated that a stable synthetic analog of 20-hydroxyeicosatetraenoic acid (20-HETE), N-(20-hydroxyeicosa-5[Z],14[Z]-dienoyl)glycine (5,14-HEDGE), which mimics the effects of endogenously produced 20-HETE, prevents vascular hyporeactivity, hypotension, tachycardia, inflammation, and mortality in a rodent model of septic shock. The present study was performed to determine whether decreased renal and cardiovascular expression and activity of myeloid differentiation factor 88 (MyD88)/transforming growth factor-activated kinase 1 (TAK1)/inhibitor of ?B (I?B) kinase ? (IKK?)/I?B-?/nuclear factor-?B (NF-?B) pathway and reduced circulating microRNA (miR)-150, miR-223, and miR-297 expression levels participate in the protective effect of 5,14-HEDGE against hypotension, tachycardia, and inflammation in response to systemic administration of lipopolysaccharide (LPS). METHODS: Conscious male Wistar rats received saline (4 ml/kg) or LPS (10 mg/kg) at time 0. Blood pressure and heart rate were measured using a tail-cuff device. Separate groups of LPS-treated rats were given 5,14-HEDGE (30 mg/kg) 1 h after injection of saline or LPS. The rats were killed 4 h after LPS challenge and blood, kidney, heart, thoracic aorta, and superior mesenteric artery were collected for measurement of the protein expression. RESULTS: LPS-induced fall in blood pressure and rise in heart rate were associated with increased MyD88 expression and phosphorylation of TAK1 and I?B-? in cytosolic fractions of the tissues. LPS also caused an increase in both unphosphorylated and phosphorylated NF-?B p65 proteins in the cytosolic and nuclear fractions as well as nuclear translocation of NF-?B p65. In addition, serum miR-150, miR-223, and miR-297 expression levels were increased in LPS-treated rats. These effects of LPS were prevented by 5,14-HEDGE. CONCLUSIONS: These results suggest that downregulation of MyD88/TAK1/IKK?/I?B-?/NF-?B pathway as well as decreased circulating miR-150, miR-223, and miR-297 expression levels participate in the protective effect of 5,14-HEDGE against hypotension, tachycardia, and inflammation in the rat model of septic shock. Twit Text FOAVip Effects of 5,14-HEDGE, a 20-HETE mimetic, on lipopolysaccharide-induced changes in MyD88/TAK1/IKK /I B- /NF- B pathway and circulating miR-150, miR-223, and miR-297 levels in a rat model of septic shock ????Inflamm Res http://www.kidney.de/pget.php?&tw=1&pmid=24915805 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24915805 #FOAvip English Wikipedia <ref>{{Cite pmid|24915805 }}</ref> Effects of 5,14-HEDGE, a 20-HETE mimetic, on lipopolysaccharide-induced changes in MyD88/TAK1/IKK?/I?B-?/NF-?B pathway and circulating miR-150, miR-223, and miR-297 levels in a rat model of septic shock #MMPMID24915805 Sari AN ; Korkmaz B ; Serin MS ; Kacan M ; Unsal D ; Buharalioglu CK ; Sahan Firat S ; Manthati VL ; Falck JR ; Malik KU ; Tunctan B Inflamm Res 2014[Sep]; 63 (9 ): 741-56 PMID24915805 show ga OBJECTIVES: We have previously demonstrated that a stable synthetic analog of 20-hydroxyeicosatetraenoic acid (20-HETE), N-(20-hydroxyeicosa-5[Z],14[Z]-dienoyl)glycine (5,14-HEDGE), which mimics the effects of endogenously produced 20-HETE, prevents vascular hyporeactivity, hypotension, tachycardia, inflammation, and mortality in a rodent model of septic shock. The present study was performed to determine whether decreased renal and cardiovascular expression and activity of myeloid differentiation factor 88 (MyD88)/transforming growth factor-activated kinase 1 (TAK1)/inhibitor of ?B (I?B) kinase ? (IKK?)/I?B-?/nuclear factor-?B (NF-?B) pathway and reduced circulating microRNA (miR)-150, miR-223, and miR-297 expression levels participate in the protective effect of 5,14-HEDGE against hypotension, tachycardia, and inflammation in response to systemic administration of lipopolysaccharide (LPS). METHODS: Conscious male Wistar rats received saline (4 ml/kg) or LPS (10 mg/kg) at time 0. Blood pressure and heart rate were measured using a tail-cuff device. Separate groups of LPS-treated rats were given 5,14-HEDGE (30 mg/kg) 1 h after injection of saline or LPS. The rats were killed 4 h after LPS challenge and blood, kidney, heart, thoracic aorta, and superior mesenteric artery were collected for measurement of the protein expression. RESULTS: LPS-induced fall in blood pressure and rise in heart rate were associated with increased MyD88 expression and phosphorylation of TAK1 and I?B-? in cytosolic fractions of the tissues. LPS also caused an increase in both unphosphorylated and phosphorylated NF-?B p65 proteins in the cytosolic and nuclear fractions as well as nuclear translocation of NF-?B p65. In addition, serum miR-150, miR-223, and miR-297 expression levels were increased in LPS-treated rats. These effects of LPS were prevented by 5,14-HEDGE. CONCLUSIONS: These results suggest that downregulation of MyD88/TAK1/IKK?/I?B-?/NF-?B pathway as well as decreased circulating miR-150, miR-223, and miR-297 expression levels participate in the protective effect of 5,14-HEDGE against hypotension, tachycardia, and inflammation in the rat model of septic shock. |Animals [MESH] |Aorta, Thoracic/drug effects/metabolism [MESH] |Arterial Pressure/drug effects [MESH] |Disease Models, Animal [MESH] |Heart Rate/drug effects [MESH] |Hydroxyeicosatetraenoic Acids [MESH] |I-kappa B Kinase/metabolism [MESH] |I-kappa B Proteins/metabolism [MESH] |Kidney/drug effects/metabolism [MESH] |Lipopeptides/*pharmacology/therapeutic use [MESH] |Lipopolysaccharides [MESH] |MAP Kinase Kinase Kinases/metabolism [MESH] |Male [MESH] |Mesenteric Artery, Superior/drug effects/metabolism [MESH] |MicroRNAs/blood [MESH] |Myeloid Differentiation Factor 88/metabolism [MESH] |Myocardium/metabolism [MESH] |Protective Agents/*pharmacology/therapeutic use [MESH] |Rats, Wistar [MESH] |Shock, Septic/blood/drug therapy/*metabolism/physiopathology [MESH]Effects of 5,14-HEDGE, a 20-HETE mimetic, on lipopolysaccharide-induce(epmc).pdf DeepDyve Pubget Overpricing