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10.1016/j.celrep.2014.04.029 http://scihub22266oqcxt.onion/10.1016/j.celrep.2014.04.029 C4157997!4157997!24910428     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep 2014 ; 7 (6): 1849-57 Nephropedia Template TP {{tp|p=24910428|t=2014. Modularized Functions of the Fanconi Anemia Core Complex |pdf=|usr=}}{{24910428}} gab.com Text Modularized Functions of the Fanconi Anemia Core Complex JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=24910428 #FOAvip The Fanconi Anemia (FA) core complex provides the essential E3 ligase function for the FA pathway activation through the spatially defined FANCD2 ubiquitination. Of the seven FA gene products forming the core complex, FANCL possesses a RING domain with demonstrated E3 ligase activity. The other six components have no clearly defined roles. Through epistatic analyses, we identified three functional modules in the FA core complex: a catalytic module consisting of FANCL, FANCB, and FAAP100 is absolutely required for the E3 ligase function; the FANCA-FANCG-FAAP20 module and the FANCC-FANCE-FANCF module provide non-redundant and ancillary functions supporting the chromatin and DNA damage association of the catalytic module. Disruption of the catalytic module renders total loss of the core complex function whereas loss of any ancillary module component does not. Our work revealed the roles of several FA gene products with previously undefined functions and a modularized assembly of the FA core complex. Twit Text FOAVip Modularized Functions of the Fanconi Anemia Core Complex ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=24910428 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24910428 #FOAvip English Wikipedia <ref>{{Cite pmid|24910428}}</ref> Modularized Functions of the Fanconi Anemia Core Complex #MMPMID24910428 Huang Y; Leung JW; Lowery M; Matsushita N; Wang Y; Shen X; Huong D; Takata M; Chen J; Li L Cell Rep 2014[Jun]; 7 (6): 1849-57 PMID24910428show ga The Fanconi Anemia (FA) core complex provides the essential E3 ligase function for the FA pathway activation through the spatially defined FANCD2 ubiquitination. Of the seven FA gene products forming the core complex, FANCL possesses a RING domain with demonstrated E3 ligase activity. The other six components have no clearly defined roles. Through epistatic analyses, we identified three functional modules in the FA core complex: a catalytic module consisting of FANCL, FANCB, and FAAP100 is absolutely required for the E3 ligase function; the FANCA-FANCG-FAAP20 module and the FANCC-FANCE-FANCF module provide non-redundant and ancillary functions supporting the chromatin and DNA damage association of the catalytic module. Disruption of the catalytic module renders total loss of the core complex function whereas loss of any ancillary module component does not. Our work revealed the roles of several FA gene products with previously undefined functions and a modularized assembly of the FA core complex. äModularized Functions of the Fanconi Anemia Core Complex (epmc).pdf DeepDyve Pubget Overpricing