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10.1038/nbt.2884 http://scihub22266oqcxt.onion/10.1038/nbt.2884 C4157757!4157757!24681508     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Biotechnol 2014 ; 32 (6): 551-3 Nephropedia Template TP {{tp|p=24681508|t=2014. Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype |pdf=|usr=}}{{24681508}} gab.com Text Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype JO: Nat Biotechnol http://www.kidney.de/pget.php?&tw=1&pmid=24681508 #FOAvip We demonstrate CRISPR-Cas9?mediated correction of a Fah mutation in hepatocytes in a mouse model of the human disease hereditary tyrosinemia. Delivery of components of the CRISPR-Cas9 system by hydrodynamic injection resulted in initial expression of the wild-type Fah protein in ~1/250 liver cells. Expansion of Fah-positive hepatocytes rescued the body weight loss phenotype. Our study indicates that CRISPR-Cas9?mediated genome editing is possible in adult animals and has potential for correction of human genetic diseases. Twit Text FOAVip Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype ????Nat Biotechnol http://www.kidney.de/pget.php?&tw=1&pmid=24681508 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24681508 #FOAvip English Wikipedia <ref>{{Cite pmid|24681508}}</ref> Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype #MMPMID24681508 Yin H; Xue W; Chen S; Bogorad RL; Benedetti E; Grompe M; Koteliansky V; Sharp PA; Jacks T; Anderson DG Nat Biotechnol 2014[Jun]; 32 (6): 551-3 PMID24681508show ga We demonstrate CRISPR-Cas9?mediated correction of a Fah mutation in hepatocytes in a mouse model of the human disease hereditary tyrosinemia. Delivery of components of the CRISPR-Cas9 system by hydrodynamic injection resulted in initial expression of the wild-type Fah protein in ~1/250 liver cells. Expansion of Fah-positive hepatocytes rescued the body weight loss phenotype. Our study indicates that CRISPR-Cas9?mediated genome editing is possible in adult animals and has potential for correction of human genetic diseases. äGenome editing with Cas9 in adult mice corrects a disease mutation and(epmc).pdf DeepDyve Pubget Overpricing