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10.1016/j.leukres.2014.05.004

http://scihub22266oqcxt.onion/10.1016/j.leukres.2014.05.004
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C4157130!4157130!25088808
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suck abstract from ncbi


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pmid25088808      Leuk+Res 2014 ; 38 (9): 1091-6
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  • Genomic Aberrations in Myeloid Sarcoma without Blood or Bone Marrow Involvement: Characterization of Formalin-Fixed Paraffin-Embedded Samples by Chromosomal Microarrays #MMPMID25088808
  • Mirza MK; Sukhanova M; Stölzel F; Onel K; Larson RA; Stock W; Ehninger G; Kuithan F; Zöphel K; Reddy P; Joseph L; Raca G
  • Leuk Res 2014[Sep]; 38 (9): 1091-6 PMID25088808show ga
  • Myeloid sarcoma (MS) is a presentation of acute myeloid leukemia (AML) as a tumor mass outside of the bone marrow. Viable cells from MS are frequently unavailable for cytogenetic studies. We therefore investigated whether chromosomal microarray analysis (CMA) using formalin-fixed paraffin-embedded (FFPE) tissues can detect clinically important genetic abnormalities in MS. CMA successfully identified genomic aberrations in six cases of MS, and in two cases it revealed multiple abnormalities equivalent to a complex karyotype, thus predicting a poor outcome. CMA using FFPE material is therefore a feasible and clinically applicable approach for detection of prognostically significant genomic abnormalities in MS.
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