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10.4049/jimmunol.1401102 http://scihub22266oqcxt.onion/10.4049/jimmunol.1401102 C4157079!4157079 !25127859     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25127859 &cmd=llinks): Failed to open stream: HTTP request failed! 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Release of active TGF-?1 from the latent TGF-?1/GARP complex on T regulatory cells is mediated by integrin ?8 |pdf=|usr=}}{{25127859 }} gab.com Text Release of active TGF- 1 from the latent TGF- 1/GARP complex on T regulatory cells is mediated by integrin 8 JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25127859 #FOAvip Activated T regulatory cells (Tregs) express latent TGF-?1 on their cell surface bound to GARP. Although integrins have been implicated in mediating the release of active TGF-?1 from the complex of latent TGF-?1 and latent TGF-?1 binding protein, their role in processing latent TGF-?1 from the latent TGF-?1/GARP complex is unclear. Mouse CD4(+)Foxp3(+) Treg, but not CD4(+)Foxp3(-) T cells, expressed integrin ?8 (Itgb8) as detected by quantitative RT-PCR. Itgb8 expression was a marker of thymically derived (t)Treg, because it could not be detected on Foxp3(+)Helios(-) Tregs or on Foxp3(+) T cells induced in vitro. Tregs from Itgb8 conditional knockouts exhibited normal suppressor function in vitro and in vivo in a model of colitis but failed to provide TGF-?1 to drive Th17 or induced Treg differentiation in vitro. In addition, Itgb8 knockout Tregs expressed higher levels of latent TGF-?1 on their cell surface consistent with defective processing. Thus, integrin ?v?8 is a marker of tTregs and functions in a cell intrinsic manner in mediating the processing of latent TGF-?1 from the latent TGF-?1/GARP complex on the surface of tTregs. Twit Text FOAVip Release of active TGF- 1 from the latent TGF- 1/GARP complex on T regulatory cells is mediated by integrin 8 ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25127859 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25127859 #FOAvip English Wikipedia <ref>{{Cite pmid|25127859 }}</ref> Release of active TGF-?1 from the latent TGF-?1/GARP complex on T regulatory cells is mediated by integrin ?8 #MMPMID25127859 Edwards JP ; Thornton AM ; Shevach EM J Immunol 2014[Sep]; 193 (6 ): 2843-9 PMID25127859 show ga Activated T regulatory cells (Tregs) express latent TGF-?1 on their cell surface bound to GARP. Although integrins have been implicated in mediating the release of active TGF-?1 from the complex of latent TGF-?1 and latent TGF-?1 binding protein, their role in processing latent TGF-?1 from the latent TGF-?1/GARP complex is unclear. Mouse CD4(+)Foxp3(+) Treg, but not CD4(+)Foxp3(-) T cells, expressed integrin ?8 (Itgb8) as detected by quantitative RT-PCR. Itgb8 expression was a marker of thymically derived (t)Treg, because it could not be detected on Foxp3(+)Helios(-) Tregs or on Foxp3(+) T cells induced in vitro. Tregs from Itgb8 conditional knockouts exhibited normal suppressor function in vitro and in vivo in a model of colitis but failed to provide TGF-?1 to drive Th17 or induced Treg differentiation in vitro. In addition, Itgb8 knockout Tregs expressed higher levels of latent TGF-?1 on their cell surface consistent with defective processing. Thus, integrin ?v?8 is a marker of tTregs and functions in a cell intrinsic manner in mediating the processing of latent TGF-?1 from the latent TGF-?1/GARP complex on the surface of tTregs. |Animals [MESH] |Biomarkers [MESH] |Cell Differentiation/immunology [MESH] |Colitis/immunology [MESH] |DNA-Binding Proteins/biosynthesis [MESH] |Forkhead Transcription Factors/biosynthesis [MESH] |Green Fluorescent Proteins/genetics [MESH] |Integrin beta Chains/biosynthesis/genetics/*immunology [MESH] |Integrins/*immunology [MESH] |Lymphocyte Activation/immunology [MESH] |Membrane Proteins/*immunology [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Mice, Knockout [MESH] |T-Lymphocytes, Regulatory/*immunology [MESH] |Th17 Cells/immunology [MESH] |Transcription Factors/biosynthesis [MESH]Release of active TGF-?1 from the latent TGF-?1/GARP complex on T regu(epmc).pdf DeepDyve Pubget Overpricing