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10.1074/jbc.M114.580357

http://scihub22266oqcxt.onion/10.1074/jbc.M114.580357
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C4155663!4155663!25049227
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suck abstract from ncbi


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pmid25049227      J+Biol+Chem 2014 ; 289 (36): 24944-55
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  • Proteasome Dysfunction Activates Autophagy and the Keap1-Nrf2 Pathway* #MMPMID25049227
  • Kageyama S; Sou Ys; Uemura T; Kametaka S; Saito T; Ishimura R; Kouno T; Bedford L; Mayer RJ; Lee MS; Yamamoto M; Waguri S; Tanaka K; Komatsu M
  • J Biol Chem 2014[Sep]; 289 (36): 24944-55 PMID25049227show ga
  • Background: Malfunctions in the ubiquitin-proteasome system cause accumulation of non-functional, potentially toxic protein aggregates.Results: The protein aggregates activate Nrf2 and are then excluded by autophagy in vivo.Conclusion: Both Nrf2 and autophagy serve as in vivo cellular adaptations to impaired proteasome.Significance: Cells contain networks of cellular defense mechanisms against defective proteostasis.
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