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10.1074/jbc.M114.565929

http://scihub22266oqcxt.onion/10.1074/jbc.M114.565929
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C4155653!4155653!25012652
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suck abstract from ncbi


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pmid25012652      J+Biol+Chem 2014 ; 289 (36): 24832-44
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  • Identification and Functional Characterization of Nuclear Mortalin in Human Carcinogenesis* #MMPMID25012652
  • Ryu J; Kaul Z; Yoon AR; Liu Y; Yaguchi T; Na Y; Ahn HM; Gao R; Choi IK; Yun CO; Kaul SC; Wadhwa R
  • J Biol Chem 2014[Sep]; 289 (36): 24832-44 PMID25012652show ga
  • Background: Mortalin/mtHsp70 is an essential stress chaperone frequently enriched in cancers.Results: Mortalin is present in the nucleus of cancer cells where it causes strong inactivation of tumor suppressor protein p53 and activation of telomerase and heterogeneous ribonucleoprotein K (hnRNP-K) proteins.Conclusion: Nuclear mortalin promotes carcinogenesis.Significance: This study is important for the development of mortalin-based anticancer treatments.
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