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10.1093/ejcts/ezt649 http://scihub22266oqcxt.onion/10.1093/ejcts/ezt649 C4155438!4155438 !24482389     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24482389 &cmd=llinks): Failed to open stream: HTTP request failed! 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Tumours of the thymus: a cohort study of prognostic factors from the European Society of Thoracic Surgeons database |pdf=|usr=}}{{24482389 }} gab.com Text Tumours of the thymus: a cohort study of prognostic factors from the European Society of Thoracic Surgeons database JO: Eur J Cardiothorac Surg http://www.kidney.de/pget.php?&tw=1&pmid=24482389 #FOAvip OBJECTIVES: A retrospective database was developed by the European Society of Thoracic Surgeons, collecting patients submitted to surgery for thymic tumours to analyse clinico-pathological prognostic predictors. METHODS: A total of 2151 incident cases from 35 institutions were collected from 1990 to 2010. Clinical-pathological characteristics were analysed, including age, gender, associated myasthenia gravis stage (Masaoka), World Health Organization histology, type of thymic tumour [thymoma, thymic carcinoma (TC), neuroendocrine thymic tumour (NETT)], type of resection (complete/incomplete), tumour size, adjuvant therapy and recurrence. Primary outcome was overall survival (OS); secondary outcomes were the proportion of incomplete resections, disease-free survival and the cumulative incidence of recurrence (CIR). RESULTS: A total of 2030 patients were analysed for OS (1798 thymomas, 191 TCs and 41 NETTs). Ten-year OS was 0.73 (95% confidence interval 0.69-0.75). Complete resection (R0) was achieved in 88% of the patients. Ten-year CIR was 0.12 (0.10-0.15). Predictors of shorter OS were increased age (P < 0-001), stage [III vs I HR 2.66, 1.80-3.92; IV vs I hazard ratio (HR) 4.41, 2.67-7.26], TC (HR 2.39, 1.68-3.40) and NETT (HR 2.59, 1.35-4.99) vs thymomas and incomplete resection (HR 1.74, 1.18-2.57). Risk of recurrence increased with tumour size (P = 0.003), stage (III vs I HR 5.67, 2.80-11.45; IV vs I HR 13.08, 5.70-30.03) and NETT (HR 7.18, 3.48-14.82). Analysis using a propensity score indicates that the administration of adjuvant therapy was beneficial in increasing OS (HR 0.69, 0.49-0.97) in R0 resections. CONCLUSIONS: Masaoka stages III-IV, incomplete resection and non-thymoma histology showed a significant impact in increasing recurrence and in worsening survival. The administration of adjuvant therapy after complete resection is associated with improved survival. Twit Text FOAVip Tumours of the thymus: a cohort study of prognostic factors from the European Society of Thoracic Surgeons database ????Eur J Cardiothorac Surg http://www.kidney.de/pget.php?&tw=1&pmid=24482389 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24482389 #FOAvip English Wikipedia <ref>{{Cite pmid|24482389 }}</ref> Tumours of the thymus: a cohort study of prognostic factors from the European Society of Thoracic Surgeons database #MMPMID24482389 Ruffini E ; Detterbeck F ; Van Raemdonck D ; Rocco G ; Thomas P ; Weder W ; Brunelli A ; Evangelista A ; Venuta F Eur J Cardiothorac Surg 2014[Sep]; 46 (3 ): 361-8 PMID24482389 show ga OBJECTIVES: A retrospective database was developed by the European Society of Thoracic Surgeons, collecting patients submitted to surgery for thymic tumours to analyse clinico-pathological prognostic predictors. METHODS: A total of 2151 incident cases from 35 institutions were collected from 1990 to 2010. Clinical-pathological characteristics were analysed, including age, gender, associated myasthenia gravis stage (Masaoka), World Health Organization histology, type of thymic tumour [thymoma, thymic carcinoma (TC), neuroendocrine thymic tumour (NETT)], type of resection (complete/incomplete), tumour size, adjuvant therapy and recurrence. Primary outcome was overall survival (OS); secondary outcomes were the proportion of incomplete resections, disease-free survival and the cumulative incidence of recurrence (CIR). RESULTS: A total of 2030 patients were analysed for OS (1798 thymomas, 191 TCs and 41 NETTs). Ten-year OS was 0.73 (95% confidence interval 0.69-0.75). Complete resection (R0) was achieved in 88% of the patients. Ten-year CIR was 0.12 (0.10-0.15). Predictors of shorter OS were increased age (P < 0-001), stage [III vs I HR 2.66, 1.80-3.92; IV vs I hazard ratio (HR) 4.41, 2.67-7.26], TC (HR 2.39, 1.68-3.40) and NETT (HR 2.59, 1.35-4.99) vs thymomas and incomplete resection (HR 1.74, 1.18-2.57). Risk of recurrence increased with tumour size (P = 0.003), stage (III vs I HR 5.67, 2.80-11.45; IV vs I HR 13.08, 5.70-30.03) and NETT (HR 7.18, 3.48-14.82). Analysis using a propensity score indicates that the administration of adjuvant therapy was beneficial in increasing OS (HR 0.69, 0.49-0.97) in R0 resections. CONCLUSIONS: Masaoka stages III-IV, incomplete resection and non-thymoma histology showed a significant impact in increasing recurrence and in worsening survival. The administration of adjuvant therapy after complete resection is associated with improved survival. |Aged [MESH] |Databases, Factual [MESH] |Female [MESH] |Humans [MESH] |Male [MESH] |Middle Aged [MESH] |Myasthenia Gravis/diagnosis [MESH] |Neoplasm Recurrence, Local/pathology [MESH] |Neoplasm Staging [MESH] |Neuroendocrine Tumors/classification/diagnosis/surgery [MESH] |Prognosis [MESH] |Retrospective Studies [MESH] |Survival Analysis [MESH] |Thymoma/classification/diagnosis/surgery [MESH]Tumours of the thymus: a cohort study of prognostic factors from the E(epmc).pdf DeepDyve Pubget Overpricing