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10.1158/0008-5472.CAN-14-1547 http://scihub22266oqcxt.onion/10.1158/0008-5472.CAN-14-1547 C4154994!4154994!25038227     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cancer+Res 2014 ; 74 (17): 4741-51 Nephropedia Template TP {{tp|p=25038227|t=2014. NACK is an integral component of the Notch transcriptional activation complex and is critical for development and tumorigenesis |pdf=|usr=}}{{25038227}} gab.com Text NACK is an integral component of the Notch transcriptional activation complex and is critical for development and tumorigenesis JO: Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=25038227 #FOAvip The Notch signaling pathway governs many distinct cellular processes by regulating transcriptional programs. The transcriptional response initiated by Notch is highly cell context dependent, indicating that multiple factors influence Notch target gene selection and activity. However, the mechanism by which Notch drives target gene transcription is not well understood. Herein, we identify and characterize a novel Notch-interacting protein, NACK, which acts as a Notch transcriptional co-activator. We show that NACK associates with the Notch transcriptional activation complex on DNA, mediates Notch transcriptional activity, and is required for Notch-mediated tumorigenesis. We demonstrate that Notch1 and NACK are co-expressed during mouse development and that homozygous loss of NACK is embryonic lethal. Finally, we show that NACK is also a Notch target gene, establishing a feed forward loop. Thus, our data indicate that NACK is a key component of the Notch transcriptional complex and is an essential regulator of Notch-mediated tumorigenesis and development. Twit Text FOAVip NACK is an integral component of the Notch transcriptional activation complex and is critical for development and tumorigenesis ????Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=25038227 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25038227 #FOAvip English Wikipedia <ref>{{Cite pmid|25038227}}</ref> NACK is an integral component of the Notch transcriptional activation complex and is critical for development and tumorigenesis #MMPMID25038227 Weaver KL; Alves-Guerra MC; Jin K; Wang Z; Han X; Ranganathan P; Zhu X; DaSilva T; Liu W; Ratti F; Demarest RM; Tzimas C; Rice M; Vasquez-Del Carpio R; Dahmane N; Robbins DJ; Capobianco AJ Cancer Res 2014[Sep]; 74 (17): 4741-51 PMID25038227show ga The Notch signaling pathway governs many distinct cellular processes by regulating transcriptional programs. The transcriptional response initiated by Notch is highly cell context dependent, indicating that multiple factors influence Notch target gene selection and activity. However, the mechanism by which Notch drives target gene transcription is not well understood. Herein, we identify and characterize a novel Notch-interacting protein, NACK, which acts as a Notch transcriptional co-activator. We show that NACK associates with the Notch transcriptional activation complex on DNA, mediates Notch transcriptional activity, and is required for Notch-mediated tumorigenesis. We demonstrate that Notch1 and NACK are co-expressed during mouse development and that homozygous loss of NACK is embryonic lethal. Finally, we show that NACK is also a Notch target gene, establishing a feed forward loop. Thus, our data indicate that NACK is a key component of the Notch transcriptional complex and is an essential regulator of Notch-mediated tumorigenesis and development. äNACK is an integral component of the Notch transcriptional activation (epmc).pdf DeepDyve Pubget Overpricing