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Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Clin+Endocrinol+Metab 2014 ; 99 (9): 3240-6 Nephropedia Template TP
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Association of Adenovirus 36 Infection With Adiposity and Inflammatory-Related Markers in Children #MMPMID24926952
Berger PK; Pollock NK; Laing EM; Warden SJ; Hill Gallant KM; Hausman DB; Tripp RA; McCabe LD; McCabe GP; Weaver CM; Peacock M; Lewis RD
J Clin Endocrinol Metab 2014[Sep]; 99 (9): 3240-6 PMID24926952show ga
Context:: Although animal studies suggest that adenovirus 36 (Ad36) infection is linked to obesity and systemic inflammation, human data are scant and equivocal. Objective:: Associations of Ad36 infection with total body adiposity and inflammatory-related markers were determined in 291 children aged 9?13 years (50% female, 49% black). Design:: Fasting blood samples were measured for presence of Ad36-specific antibodies and TNF-?, IL-6, vascular endothelial growth factor (VEGF), and monocyte chemoattractant protein-1 (MCP-1). Fat mass and fat-free soft tissue mass were measured by dual-energy X-ray absorptiometry. Results:: The overall prevalence of Ad36 seropositivity [Ad36(+)] was 42%. There was a higher percentage of Ad36(+) children in the highest tertiles of TNF-? and IL-6 compared with their respective middle and lowest tertiles (both P < .03). There was also a trend toward a higher prevalence of Ad36(+) children in the highest tertile of VEGF compared with tertiles 1 and 2 (P = .05). Multinomial logistic regression, adjusting for age, race, sex, and fat-free soft tissue mass, revealed that compared with children with the lowest TNF-?, IL-6, and VEGF levels (tertile 1), the adjusted odds ratios for Ad36(+) were 2.2 [95% confidence interval (CI) 1.2?4.0], 2.4 (95% CI 1.4?4.0), and 1.8 (95% CI 1.0?3.3), respectively, for those in the highest TNF-?, IL-6, and VEGF levels (tertile 3). No association was observed between Ad36(+) and greater levels of fat mass or MCP-1 (all P > .05). Conclusions:: In children, our data suggest that Ad36(+) may be associated with biomarkers implicated in inflammation but not with greater levels of fat mass.