Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24871858
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24871858
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Am+J+Physiol+Cell+Physiol
2014 ; 307
(5
): C415-30
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Identification of a common Wnt-associated genetic signature across multiple cell
types in pulmonary arterial hypertension
#MMPMID24871858
West JD
; Austin ED
; Gaskill C
; Marriott S
; Baskir R
; Bilousova G
; Jean JC
; Hemnes AR
; Menon S
; Bloodworth NC
; Fessel JP
; Kropski JA
; Irwin D
; Ware LB
; Wheeler L
; Hong CC
; Meyrick B
; Loyd JE
; Bowman AB
; Ess KC
; Klemm DJ
; Young PP
; Merryman WD
; Kotton D
; Majka SM
Am J Physiol Cell Physiol
2014[Sep]; 307
(5
): C415-30
PMID24871858
show ga
Understanding differences in gene expression that increase risk for pulmonary
arterial hypertension (PAH) is essential to understanding the molecular basis for
disease. Previous studies on patient samples were limited by end-stage disease
effects or by use of nonadherent cells, which are not ideal to model vascular
cells in vivo. These studies addressed the hypothesis that pathological processes
associated with PAH may be identified via a genetic signature common across
multiple cell types. Expression array experiments were initially conducted to
analyze cell types at different stages of vascular differentiation (mesenchymal
stromal and endothelial) derived from PAH patient-specific induced pluripotent
stem (iPS) cells. Molecular pathways that were altered in the PAH cell lines were
then compared with those in fibroblasts from 21 patients, including those with
idiopathic and heritable PAH. Wnt was identified as a target pathway and was
validated in vitro using primary patient mesenchymal and endothelial cells. Taken
together, our data suggest that the molecular lesions that cause PAH are present
in all cell types evaluated, regardless of origin, and that stimulation of the
Wnt signaling pathway was a common molecular defect in both heritable and
idiopathic PAH.