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10.1097/BOR.0000000000000088 http://scihub22266oqcxt.onion/10.1097/BOR.0000000000000088 C4153426!4153426!24992143     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Curr+Opin+Rheumatol 2014 ; 26 (5): 475-81 Nephropedia Template TP {{tp|p=24992143|t=2014. The Inflammasome and lupus- another innate immune mechanism contributing to disease pathogenesis?|pdf=|usr=}}{{24992143}} gab.com Text The Inflammasome and lupus- another innate immune mechanism contributing to disease pathogenesis JO: Curr Opin Rheumatol http://www.kidney.de/pget.php?&tw=1&pmid=24992143 #FOAvip Purpose of review: The role of innate immunity in systemic lupus erythematosus (SLE) has been a rapidly expanding area of research over the last decade. Included in this rubric is the concept that activation of the inflammasome, a molecular complex that activates caspase-1 and in turn, the cytokines IL-1? and IL-18, is important in lupus pathogenesis. This review will summarize recent discoveries exploring the role of the inflammasome machinery in SLE. Recent findings: Immune complexes can activate the NLRP3 inflammasome, and SLE-derived macrophages are hyper-responsive to innate immune stimuli, leading to enhanced activation of the inflammasome and production of inflammatory cytokines. Work in several murine models suggests an important role for the NLRP3 inflammasome in mediating lupus nephritis. Caspase-1, the central enzyme of the inflammasome, is essential for development of type I interferon responses, autoantibody production and nephritis in the pristane model of lupus. The AIM2 inflammasome may have protective and pathogenic roles in SLE. Summary: Recent evidence suggests that the inflammasome machinery is dysregulated in SLE, plays an important role in promotion of organ damage, and may mediate cross-talk between environmental triggers and the development of lupus. Further research should focus on whether inhibition of inflammasome components may serve as a viable target for therapeutic development in SLE. Twit Text FOAVip The Inflammasome and lupus- another innate immune mechanism contributing to disease pathogenesis ????Curr Opin Rheumatol http://www.kidney.de/pget.php?&tw=1&pmid=24992143 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24992143 #FOAvip English Wikipedia <ref>{{Cite pmid|24992143}}</ref> The Inflammasome and lupus- another innate immune mechanism contributing to disease pathogenesis? #MMPMID24992143 Kahlenberg JM; Kaplan MJ Curr Opin Rheumatol 2014[Sep]; 26 (5): 475-81 PMID24992143show ga Purpose of review: The role of innate immunity in systemic lupus erythematosus (SLE) has been a rapidly expanding area of research over the last decade. Included in this rubric is the concept that activation of the inflammasome, a molecular complex that activates caspase-1 and in turn, the cytokines IL-1? and IL-18, is important in lupus pathogenesis. This review will summarize recent discoveries exploring the role of the inflammasome machinery in SLE. Recent findings: Immune complexes can activate the NLRP3 inflammasome, and SLE-derived macrophages are hyper-responsive to innate immune stimuli, leading to enhanced activation of the inflammasome and production of inflammatory cytokines. Work in several murine models suggests an important role for the NLRP3 inflammasome in mediating lupus nephritis. Caspase-1, the central enzyme of the inflammasome, is essential for development of type I interferon responses, autoantibody production and nephritis in the pristane model of lupus. The AIM2 inflammasome may have protective and pathogenic roles in SLE. Summary: Recent evidence suggests that the inflammasome machinery is dysregulated in SLE, plays an important role in promotion of organ damage, and may mediate cross-talk between environmental triggers and the development of lupus. Further research should focus on whether inhibition of inflammasome components may serve as a viable target for therapeutic development in SLE. äThe Inflammasome and lupus- another innate immune mechanism contributi(epmc).pdf DeepDyve Pubget Overpricing