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10.1097/SLA.0000000000000871 http://scihub22266oqcxt.onion/10.1097/SLA.0000000000000871 C4152867!4152867!25115419     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Ann+Surg 2014 ; 260 (3): 432-44 Nephropedia Template TP {{tp|p=25115419|t=2014. The Enteric Nervous System (ENS) Neuropeptide, Bombesin (BBS), Reverses Innate Immune Impairments during Parenteral Nutrition (PN) |pdf=|usr=}}{{25115419}} gab.com Text The Enteric Nervous System (ENS) Neuropeptide, Bombesin (BBS), Reverses Innate Immune Impairments during Parenteral Nutrition (PN) JO: Ann Surg http://www.kidney.de/pget.php?&tw=1&pmid=25115419 #FOAvip Introduction: Lack of enteral stimulation during PN impairs acquired (e.g. IgA) and innate mucosal immunity providing a cogent explanation for increased infections in PN fed patients compared to enteral feeding. Experimentally, BBS, a gastrin-releasing neuropeptide analogue, reverses PN-induced defects in gut and respiratory acquired immunity. Paneth cells produce and store the key bactericidal peptides of innate immunity for release into the lumen after cholinergic stimulation. We hypothesized that BBS during PN restores antimicrobial peptides (AMPs) and the bactericidal function of innate immunity. Methods: IV cannulated male ICR mice were randomized to Chow, PN, or PN + 15 ?g TID BBS (n=7 per group) for 5 days. Ileal tissue was analyzed for AMPs (Protein levels: sPLA2 by fluorescence, lysozyme and RegIII-? by western, and cryptdin-4 by ELISA; mRNA: all by RT-PCR). Ileal tissue stimulated with a cholinergic agonist (100 ?M bethanechol) assessed Pseudomonas bactericidal activity. Additional mice (Chow: n=7; PN: n=9; PN+BBS: n=8) were assessed for E. coli intestinal invasion in ex-vivo culture. Results: Compared to chow, PN significantly decreased cellular levels of AMPs while BBS maintained them at Chow levels. Functionally, BBS prevented PN loss of bactericidal activity after cholinergic stimulation but failed to improve bacterial enteroinvasion in unstimulated tissue. Conclusions: The ENS controls AMP levels in Paneth cells during PN but both ENS and parasympathetic stimulation are required for mucosal protection by innate immunity. Twit Text FOAVip The Enteric Nervous System (ENS) Neuropeptide, Bombesin (BBS), Reverses Innate Immune Impairments during Parenteral Nutrition (PN) ????Ann Surg http://www.kidney.de/pget.php?&tw=1&pmid=25115419 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25115419 #FOAvip English Wikipedia <ref>{{Cite pmid|25115419}}</ref> The Enteric Nervous System (ENS) Neuropeptide, Bombesin (BBS), Reverses Innate Immune Impairments during Parenteral Nutrition (PN) #MMPMID25115419 Busch RA; Heneghan AF; Pierre JF; Wang X; Kudsk KA Ann Surg 2014[Sep]; 260 (3): 432-44 PMID25115419show ga Introduction: Lack of enteral stimulation during PN impairs acquired (e.g. IgA) and innate mucosal immunity providing a cogent explanation for increased infections in PN fed patients compared to enteral feeding. Experimentally, BBS, a gastrin-releasing neuropeptide analogue, reverses PN-induced defects in gut and respiratory acquired immunity. Paneth cells produce and store the key bactericidal peptides of innate immunity for release into the lumen after cholinergic stimulation. We hypothesized that BBS during PN restores antimicrobial peptides (AMPs) and the bactericidal function of innate immunity. Methods: IV cannulated male ICR mice were randomized to Chow, PN, or PN + 15 ?g TID BBS (n=7 per group) for 5 days. Ileal tissue was analyzed for AMPs (Protein levels: sPLA2 by fluorescence, lysozyme and RegIII-? by western, and cryptdin-4 by ELISA; mRNA: all by RT-PCR). Ileal tissue stimulated with a cholinergic agonist (100 ?M bethanechol) assessed Pseudomonas bactericidal activity. Additional mice (Chow: n=7; PN: n=9; PN+BBS: n=8) were assessed for E. coli intestinal invasion in ex-vivo culture. Results: Compared to chow, PN significantly decreased cellular levels of AMPs while BBS maintained them at Chow levels. Functionally, BBS prevented PN loss of bactericidal activity after cholinergic stimulation but failed to improve bacterial enteroinvasion in unstimulated tissue. Conclusions: The ENS controls AMP levels in Paneth cells during PN but both ENS and parasympathetic stimulation are required for mucosal protection by innate immunity. äThe Enteric Nervous System (ENS) Neuropeptide, Bombesin (BBS), Reverse(epmc).pdf DeepDyve Pubget Overpricing