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10.1097/SLA.0000000000000871 http://scihub22266oqcxt.onion/10.1097/SLA.0000000000000871 C4152867!4152867 !25115419     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25115419 &cmd=llinks): Failed to open stream: HTTP request failed! 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The enteric nervous system neuropeptide, bombesin, reverses innate immune impairments during parenteral nutrition |pdf=|usr=}}{{25115419 }} gab.com Text The enteric nervous system neuropeptide, bombesin, reverses innate immune impairments during parenteral nutrition JO: Ann Surg http://www.kidney.de/pget.php?&tw=1&pmid=25115419 #FOAvip BACKGROUND: Lack of enteral stimulation during parenteral nutrition (PN) impairs mucosal immunity. Bombesin (BBS), a gastrin-releasing peptide analogue, reverses PN-induced defects in acquired immunity. Paneth cells produce antimicrobial peptides (AMPs) of innate immunity for release after cholinergic stimulation. OBJECTIVE: Determine if BBS restores AMPs and bactericidal function during PN. METHODS: Intravenously cannulated male ICR mice were randomized to Chow, PN, or PN+BBS (15 ?g 3 times daily, n = 7 per group) for 5 days. Ileum was analyzed for AMPs (Protein: sPLA2 by fluorescence, lysozyme and RegIII-? by western andcryptdin-4 by ELISA; mRNA: all by RT-PCR). Cholinergic stimulated (100 ?M bethanechol) ileal specimens assessed Pseudomonas bactericidal activity. Ileum (Chow: n = 7; PN: n = 9; PN+BBS: n = 8) was assessed for Escherichia coli invasion in ex-vivo culture. RESULTS: PN significantly decreased most AMPs versus Chow while BBS maintained Chow levels (sPLA2: Chow: 107 + 14*, PN: 44.6 + 7.2, PN+BBS: 78.7 + 13.4* Fl/min/?L/total protein; Lysozyme: Chow: 63.9 + 11.9*, PN: 26.8 + 6.2; PN+BBS: 64.9 + 13.8* lysozyme/total protein; RegIII-?: Chow: 51.5 + 10.0*, PN: 20.4 + 4.3, PN+BBS: 31.0 + 8.4 RegIII-?/total protein; Cryptdin-4: Chow: 18.4 + 1.5*, PN: 12.7 + 1.6, PN+BBS: 26.1 + 2.4*? pg/mg [all *P < 0.05 vs PN and ?P < 0.05 vs Chow]). Functionally, BBS prevented PN loss of bactericidal activity after cholinergic stimulation (Chow: 25.3 + 3.6*, PN: 13.0 + 3.2; PN+BBS: 27.0 + 4.7* percent bacterial killing, *P < 0.05 vs PN). BBS reduced bacterial invasion in unstimulated tissue barely missing significance (P = 0.06). CONCLUSIONS: The enteric nervous system (ENS) controls AMP levels in Paneth cells during PN but mucosal protection by innate immunity requires both ENS and parasympathetic stimulation. Twit Text FOAVip The enteric nervous system neuropeptide, bombesin, reverses innate immune impairments during parenteral nutrition ????Ann Surg http://www.kidney.de/pget.php?&tw=1&pmid=25115419 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25115419 #FOAvip English Wikipedia <ref>{{Cite pmid|25115419 }}</ref> The enteric nervous system neuropeptide, bombesin, reverses innate immune impairments during parenteral nutrition #MMPMID25115419 Busch RA ; Heneghan AF ; Pierre JF ; Wang X ; Kudsk KA Ann Surg 2014[Sep]; 260 (3 ): 432-43; discussion 443-4 PMID25115419 show ga BACKGROUND: Lack of enteral stimulation during parenteral nutrition (PN) impairs mucosal immunity. Bombesin (BBS), a gastrin-releasing peptide analogue, reverses PN-induced defects in acquired immunity. Paneth cells produce antimicrobial peptides (AMPs) of innate immunity for release after cholinergic stimulation. OBJECTIVE: Determine if BBS restores AMPs and bactericidal function during PN. METHODS: Intravenously cannulated male ICR mice were randomized to Chow, PN, or PN+BBS (15 ?g 3 times daily, n = 7 per group) for 5 days. Ileum was analyzed for AMPs (Protein: sPLA2 by fluorescence, lysozyme and RegIII-? by western andcryptdin-4 by ELISA; mRNA: all by RT-PCR). Cholinergic stimulated (100 ?M bethanechol) ileal specimens assessed Pseudomonas bactericidal activity. Ileum (Chow: n = 7; PN: n = 9; PN+BBS: n = 8) was assessed for Escherichia coli invasion in ex-vivo culture. RESULTS: PN significantly decreased most AMPs versus Chow while BBS maintained Chow levels (sPLA2: Chow: 107 + 14*, PN: 44.6 + 7.2, PN+BBS: 78.7 + 13.4* Fl/min/?L/total protein; Lysozyme: Chow: 63.9 + 11.9*, PN: 26.8 + 6.2; PN+BBS: 64.9 + 13.8* lysozyme/total protein; RegIII-?: Chow: 51.5 + 10.0*, PN: 20.4 + 4.3, PN+BBS: 31.0 + 8.4 RegIII-?/total protein; Cryptdin-4: Chow: 18.4 + 1.5*, PN: 12.7 + 1.6, PN+BBS: 26.1 + 2.4*? pg/mg [all *P < 0.05 vs PN and ?P < 0.05 vs Chow]). Functionally, BBS prevented PN loss of bactericidal activity after cholinergic stimulation (Chow: 25.3 + 3.6*, PN: 13.0 + 3.2; PN+BBS: 27.0 + 4.7* percent bacterial killing, *P < 0.05 vs PN). BBS reduced bacterial invasion in unstimulated tissue barely missing significance (P = 0.06). CONCLUSIONS: The enteric nervous system (ENS) controls AMP levels in Paneth cells during PN but mucosal protection by innate immunity requires both ENS and parasympathetic stimulation. |*Parenteral Nutrition [MESH] |Animals [MESH] |Bombesin/*administration & dosage [MESH] |Ileum/metabolism [MESH] |Immunity, Innate/*drug effects/physiology [MESH] |Immunity, Mucosal/drug effects [MESH] |Immunohistochemistry [MESH] |Intestinal Mucosa/*immunology [MESH] |Male [MESH] |Mice, Inbred ICR [MESH] |Muramidase/metabolism [MESH] |Neurotransmitter Agents/*administration & dosage [MESH] |Pancreatitis-Associated Proteins [MESH] |Paneth Cells/*metabolism [MESH] |Phospholipases A2, Secretory/metabolism [MESH] |Proteins/metabolism [MESH]The enteric nervous system neuropeptide, bombesin, reverses innate imm(epmc).pdf DeepDyve Pubget Overpricing