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10.2215/CJN.12581213 http://scihub22266oqcxt.onion/10.2215/CJN.12581213 C4152820!4152820!24993449     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+J+Am+Soc+Nephrol 2014 ; 9 (9): 1563-70 Nephropedia Template TP {{tp|p=24993449|t=2014. Safety and Efficacy of Tandem Hemodialysis and Plasma Exchange in Children |pdf=|usr=}}{{24993449}} gab.com Text Safety and Efficacy of Tandem Hemodialysis and Plasma Exchange in Children JO: Clin J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=24993449 #FOAvip Background and objectives: Patients with immune-mediated kidney disease and liver failure often require plasma exchange (PE) and hemodialysis (HD). Combining both methods (i.e., connecting the PE and HD circuits in series [tandem dialysis]) should allow for a more efficient treatment. This work reviews the authors? experience with tandem blood purification. Design, setting, participants, & measurements: Chart review was utilized to retrospectively analyze the efficacy and tolerability of 92 combined PE/HD (cPE/HD) sessions in 26 children in comparison with 113 sequential PE/HD (sPE/HD) treatments performed in 32 children between 1988 and 2012 at the University of Heidelberg Center for Pediatric and Adolescent Medicine. Eleven children received both treatment modalities. Results: The mean treatment duration was 3.8±2.2 hours per cPE/HD and 5.9±1.6 hours per sPE/HD session (P<0.001). Dialyzer surface areas per body surface area (in meters squared) and blood flow rates were similar. Although a 3-fold higher initial bolus of heparin was administered with cPE/HD, the heparin dose per hour was similar with both modalities and the total heparin load was only slightly lower with cPE/HD, with a median 2939 IU/m2 per session (interquartile range, 1868, 4189) versus 3341 IU/m2 per session (interquartile range, 2126, 4792). In sessions with regional anticoagulation, equal citrate and calcium infusion rates were applied. Plasma turnover, ultrafiltration rates, and solute removal were comparable. Procedure-related problems developed in 14.0% of cPE/HD and 7.0% of sPE/HD sessions (P=0.37). Clinical symptoms occurred in 19.6% and 6.2% (P=0.05), necessitating treatment discontinuation in 12.0% and 5.3% of the sessions (P=0.14). Intra-individual comparison of both dialysis methods in 11 children reconfirmed these findings. Conclusions: cPE/HD is a time-saving procedure relative to sPE/HD, but may be associated with a higher rate of procedure-related and clinical adverse events. Twit Text FOAVip Safety and Efficacy of Tandem Hemodialysis and Plasma Exchange in Children ????Clin J Am Soc Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=24993449 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24993449 #FOAvip English Wikipedia <ref>{{Cite pmid|24993449}}</ref> Safety and Efficacy of Tandem Hemodialysis and Plasma Exchange in Children #MMPMID24993449 Schaefer B; Ujszaszi A; Schaefer S; Heckert KH; Schaefer F; Schmitt CP Clin J Am Soc Nephrol 2014[Sep]; 9 (9): 1563-70 PMID24993449show ga Background and objectives: Patients with immune-mediated kidney disease and liver failure often require plasma exchange (PE) and hemodialysis (HD). Combining both methods (i.e., connecting the PE and HD circuits in series [tandem dialysis]) should allow for a more efficient treatment. This work reviews the authors? experience with tandem blood purification. Design, setting, participants, & measurements: Chart review was utilized to retrospectively analyze the efficacy and tolerability of 92 combined PE/HD (cPE/HD) sessions in 26 children in comparison with 113 sequential PE/HD (sPE/HD) treatments performed in 32 children between 1988 and 2012 at the University of Heidelberg Center for Pediatric and Adolescent Medicine. Eleven children received both treatment modalities. Results: The mean treatment duration was 3.8±2.2 hours per cPE/HD and 5.9±1.6 hours per sPE/HD session (P<0.001). Dialyzer surface areas per body surface area (in meters squared) and blood flow rates were similar. Although a 3-fold higher initial bolus of heparin was administered with cPE/HD, the heparin dose per hour was similar with both modalities and the total heparin load was only slightly lower with cPE/HD, with a median 2939 IU/m2 per session (interquartile range, 1868, 4189) versus 3341 IU/m2 per session (interquartile range, 2126, 4792). In sessions with regional anticoagulation, equal citrate and calcium infusion rates were applied. Plasma turnover, ultrafiltration rates, and solute removal were comparable. Procedure-related problems developed in 14.0% of cPE/HD and 7.0% of sPE/HD sessions (P=0.37). Clinical symptoms occurred in 19.6% and 6.2% (P=0.05), necessitating treatment discontinuation in 12.0% and 5.3% of the sessions (P=0.14). Intra-individual comparison of both dialysis methods in 11 children reconfirmed these findings. Conclusions: cPE/HD is a time-saving procedure relative to sPE/HD, but may be associated with a higher rate of procedure-related and clinical adverse events. äSafety and Efficacy of Tandem Hemodialysis and Plasma Exchange in Chil(epmc).pdf DeepDyve Pubget Overpricing