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10.1016/j.neuropharm.2014.02.016 http://scihub22266oqcxt.onion/10.1016/j.neuropharm.2014.02.016 C4152390!4152390!24594476     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Neuropharmacology 2014 ; 87 (ä): 206-13 Nephropedia Template TP {{tp|p=24594476|t=2014. Pharmacology of novel synthetic stimulants structurally related to the ?bath salts? constituent 3,4-methylenedioxypyrovalerone (MDPV) |pdf=|usr=}}{{24594476}} gab.com Text Pharmacology of novel synthetic stimulants structurally related to the bath salts constituent 3,4-methylenedioxypyrovalerone (MDPV) JO: Neuropharmacology http://www.kidney.de/pget.php?&tw=1&pmid=24594476 #FOAvip There has been a dramatic rise in the abuse of synthetic cathinones known as ?bath salts,? including 3,4-methylenedioxypyrovalerone (MDPV), an analog linked to many adverse events. MDPV differs from other synthetic cathinones because it contains a pyrrolidine ring which gives the drug potent actions as an uptake blocker at dopamine and norepinephrine transporters. While MDPV is now illegal, a wave of ?second generation? pyrrolidinophenones has appeared on the market, with ?-pyrrolidinovalerophenone (?-PVP) being most popular. Here, we sought to compare the in vitro and in vivo pharmacological effects of MDPV and its congeners: ?-PVP, ?-pyrrolidinobutiophenone (?-PBP), and ?-pyrrolidinopropiophenone (?-PPP). We examined effects of test drugs in transporter uptake and release assays using rat brain synaptosomes, then assessed behavioral stimulant effects in mice. We found that ?-PVP is a potent uptake blocker at dopamine and norepinephrine transporters, similar to MDPV. ?-PBP and ?-PPP are also catecholamine transporter blockers but display reduced potency. All of the test drugs are locomotor stimulants, and the rank order of in vivo potency parallels dopamine transporter activity, with MDPV>?-PVP>?-PBP>?-PPP. Motor activation produced by all drugs is reversed by the dopamine receptor antagonist SCH23390. Furthermore, results of a functional observational battery show that all test drugs produce typical stimulant effects at lower doses and some drugs produce bizarre behaviors at higher doses. Taken together, our findings represent the first evidence that second generation analogs of MDPV are catecholamine-selective uptake blockers which may pose risk for addiction and adverse effects in human users. Twit Text FOAVip Pharmacology of novel synthetic stimulants structurally related to the bath salts constituent 3,4-methylenedioxypyrovalerone (MDPV) ????Neuropharmacology http://www.kidney.de/pget.php?&tw=1&pmid=24594476 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24594476 #FOAvip English Wikipedia <ref>{{Cite pmid|24594476}}</ref> Pharmacology of novel synthetic stimulants structurally related to the ?bath salts? constituent 3,4-methylenedioxypyrovalerone (MDPV) #MMPMID24594476 Marusich JA; Antonazzo KR; Wiley JL; Blough BE; Partilla JS; Baumann MH Neuropharmacology 2014[Dec]; 87 (ä): 206-13 PMID24594476show ga There has been a dramatic rise in the abuse of synthetic cathinones known as ?bath salts,? including 3,4-methylenedioxypyrovalerone (MDPV), an analog linked to many adverse events. MDPV differs from other synthetic cathinones because it contains a pyrrolidine ring which gives the drug potent actions as an uptake blocker at dopamine and norepinephrine transporters. While MDPV is now illegal, a wave of ?second generation? pyrrolidinophenones has appeared on the market, with ?-pyrrolidinovalerophenone (?-PVP) being most popular. Here, we sought to compare the in vitro and in vivo pharmacological effects of MDPV and its congeners: ?-PVP, ?-pyrrolidinobutiophenone (?-PBP), and ?-pyrrolidinopropiophenone (?-PPP). We examined effects of test drugs in transporter uptake and release assays using rat brain synaptosomes, then assessed behavioral stimulant effects in mice. We found that ?-PVP is a potent uptake blocker at dopamine and norepinephrine transporters, similar to MDPV. ?-PBP and ?-PPP are also catecholamine transporter blockers but display reduced potency. All of the test drugs are locomotor stimulants, and the rank order of in vivo potency parallels dopamine transporter activity, with MDPV>?-PVP>?-PBP>?-PPP. Motor activation produced by all drugs is reversed by the dopamine receptor antagonist SCH23390. Furthermore, results of a functional observational battery show that all test drugs produce typical stimulant effects at lower doses and some drugs produce bizarre behaviors at higher doses. Taken together, our findings represent the first evidence that second generation analogs of MDPV are catecholamine-selective uptake blockers which may pose risk for addiction and adverse effects in human users. äPharmacology of novel synthetic stimulants structurally related to the(epmc).pdf DeepDyve Pubget Overpricing